Use of peptides for promoting wound healing

Abstract

The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications.

1 - 35 . (canceled) 
     
     
         36 . A composition comprising a peptide and at least one pharmaceutically acceptable excipient, wherein the peptide comprises at least six contiguous residues of the amino acid sequence of SEQ ID NO: 5 or a variant peptide thereof in which one amino acid residue is substituted, deleted or inserted within said at least six contiguous residues, wherein the peptide is a cyclic peptide. 
     
     
         37 . The composition of  claim 36 , wherein the sequence of said at least six contiguous residues is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3. 
     
     
         38 . The composition of  claim 36 , wherein the sequence of said at least six contiguous residues comprises at least six contiguous residues of SEQ ID NO: 2. 
     
     
         39 . The composition of  claim 36 , wherein the cyclic peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-29 or a variant thereof in which one amino acid residue in any of SEQ ID NOs: 4-29 is substituted, deleted or inserted and the one residue substitution, deletion or insertion is not within a subsequence of SEQ ID NOs: 1-3. 
     
     
         40 . The composition of  claim 36 , wherein the cyclic peptide has a relative wound closure activity that is equal to the relative wound closure activity of 1 μM concentration of the linear peptide of SEQ ID NO: 4 but at a concentration of cyclic peptide that is at least 5 times lower. 
     
     
         41 . The composition of  claim 36 , wherein the peptide has the sequence of SEQ ID NO: 2. 
     
     
         42 . The composition of  claim 36 , wherein the cyclic peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 4, 5, 7-20, 23-25, and 28-29 or a variant thereof in which one amino acid residue in any of SEQ ID NOs: 4, 5, 7-20, 23-25, and 28-29 is substituted, deleted or inserted and the one residue substitution, deletion or insertion is not within a subsequence of SEQ ID NO: 2.