Composition and method for control of diabetes

Abstract

Correctly formulated enterically coated nutrient pellets are able to significantly to lower the blood sugar level of type two diabetics when administered with a normal meal. The inventive composition is effective at dosage levels of 10 g or less. Effective doses of the composition contribute 42 kcal or fewer to the patient's diet. A preferred form of the composition contains lauric acid coated for release in the distal bowel. When taken. with an ordinary meal, the effective dosage does not induce the ileal brake and is more than 50 times (often more than 100 times) as effective on per kilocalorie basis as an ordinary meal at eliciting increases in PYY and GLP-1. Thus, ordinary nutrients—as opposed to drugs—can be used to reduce blood sugar levels when administered at dosage levels that are not significant promoters of weight gain.

1 . A method for lowering blood sugar levels in subjects having type-2 diabetes comprising the steps of:
 providing pellets of nutrient coated with an enteric coating formulated to release the nutrient over an extended length of the intestine of the subject; and   administering a dose of the pellets together with a meal to a subject having type-2 diabetes whereby the pellets enter the intestine of the subject along with the meal and release nutrient over an extended period of time so as to extended the length of the intestine contacted by nutrient whereby effector molecules which lower blood glucose are released.   
     
     
         2 - 37 . (canceled)