US2015299288A1PendingUtilityA1

Modified Insulin Polypeptides and Their Uses

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Assignee: AMBRX INCPriority: Nov 20, 2007Filed: Dec 19, 2014Published: Oct 22, 2015
Est. expiryNov 20, 2027(~1.4 yrs left)· nominal 20-yr term from priority
Inventors:Zhenwei MiaoDenise KrawitzVadim KraynovTian FengBee-Cheng SimLillian SkidmoreAnna-Maria A. Hays PutnamNick KnudsenMichael Deguzman
A61P 3/06A61P 3/10A61P 3/08A61P 3/00A61K 38/00C07K 14/62A61K 38/28
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Claims

Abstract

Modified insulin polypeptides and their uses thereof are provided

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . An insulin polypeptide comprising one or more non-naturally encoded amino acids. 
     
     
         2 . An insulin polypeptide wherein the A chain comprises one or more non-naturally encoded amino acids. 
     
     
         3 . An insulin polypeptide wherein the B chain comprises one or more non-naturally encoded amino acids. 
     
     
         4 . An insulin analog comprising one or more non-naturally encoded amino acids. 
     
     
         5 . A method of treating a patient with a metabolic disorder wherein the patient is administered a therapeutically effective amount of an insulin polypeptide comprising one or more non-naturally encoded amino acids.

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