Wound Care Products with Peracid Compositions

Abstract

Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound.

What is claimed is: 
     
         1 . A wound application matrix comprising a wound treatment material and an antimicrobial composition comprising a carboxylic acid, the peracid of said carboxylic acid, and an oxidizer in a non-aqueous medium. 
     
     
         2 . The wound application matrix according to  claim 1 , wherein the wound treatment material is selected from the group consisting of hydrogel bandages, hydrogel dressings, synthetic fiber bandages, cotton lace bandages, flowable and non-flowable gels, sponges, creams, pastes, colloids, liposomes, micells, carbon nanostructures, and polymeric films. 
     
     
         3 . The wound application matrix according to  claim 1 , wherein the wound treatment material comprises a dissolving film. 
     
     
         4 . The wound application matrix according to  claim 1 , further comprising: an aqueous layer; wherein the aqueous layer is separated from the antimicrobial composition prior to use; wherein in use, the antimicrobial composition is exposed to the aqueous layer, and the antimicrobial composition migrates into the aqueous layer. 
     
     
         5 . The wound application matrix according to  claim 4 , further comprising a removable fluid-resistant barrier layer for initially separating the antimicrobial composition from the aqueous layer, wherein in use, the barrier is removed to allow contact between the antimicrobial composition and the aqueous layer. 
     
     
         6 . The wound application matrix according to  claim 1 , wherein the antimicrobial composition further comprises an ester of the carboxylic acid. 
     
     
         7 . The wound application matrix according to  claim 1 , wherein the antimicrobial composition is released from the wound treatment material when contacted with a water based fluid. 
     
     
         8 . The wound application matrix according to  claim 7 , wherein the water based fluid is wound exudate. 
     
     
         9 . The wound application matrix according to  claim 1 , wherein the wound treatment material provides a controlled release of the antimicrobial composition when contacted with a water based fluid. 
     
     
         10 . The wound application matrix according to  claim 4 , wherein the aqueous layer provides a controlled delivery of the antimicrobial composition when contacted with a water based fluid or exudate. 
     
     
         11 . The wound application matrix according to  claim 4 , wherein the aqueous layer comprises a hydrogel. 
     
     
         12 . The wound application matrix according to  claim 1 , further comprising a surfactant. 
     
     
         13 . The wound application matrix according to  claim 1 , further comprising a stabilizing agent. 
     
     
         14 . The wound application matrix according to  claim 1 , further comprising an emulsifying agent. 
     
     
         15 . The wound application matrix according to  claim 1 , wherein the peracid is a peroxy a-ketocarboxylic acid. 
     
     
         16 . The wound application matrix according to  claim 15 , wherein the peroxy a-ketocarboxylic acid is selected from peroxy a-ketopyruvic acid, peroxy a-ketobutyric acid, peroxy a-ketovaleric acid, or a mixture of thereof. 
     
     
         17 . The wound application matrix according to  claim 1 , further comprising a liquid-impermeable backing layer adjacent to the antimicrobial composition. 
     
     
         18 . The wound application matrix according to  claim 17 , wherein the backing layer is adhesive-coated and provides an adhesive-coated margin around the antimicrobial composition. 
     
     
         19 . The wound application matrix according to  claim 1 , wherein the wound treatment material comprises a polymer containing a peracid. 
     
     
         20 . A method for treating a wound, comprising providing the wound application matrix according to  claim 1 , and topically applying the wound application matrix to the wound. 
     
     
         21 . A wound application matrix comprising:
 one layer comprising a peracid composition; and a second layer comprising an excipient to enhance wound healing.   
     
     
         22 . The wound application matrix according to  claim 21 , wherein the excipient to enhance wound healing comprises one or more of (1) a hemostatic drug, (2) an anti-inflammatory drug, (3) an analgesic drug, and (4) an angiogenesis drug. 
     
     
         23 . A wound application matrix comprising:
 a wound treating agent; and a peracid composition, wherein the peracid composition is encapsulated in a biocompatible structure.   
     
     
         24 . The wound application matrix according to  claim 23 , wherein the biocompatible structure is a nanostructure, liposome, or micelle. 
     
     
         25 . A wound application matrix comprising:
 a polymer; and a peracid.   
     
     
         26 . The wound application matrix according to  claim 25 , wherein the polymer is polyvinyl. 
     
     
         27 . The wound application matrix according to  claim 25 , wherein the polymer is polyurethane. 
     
     
         28 . The wound application matrix according to  claim 25 , wherein the polymer is a resin or protein.