External skin agent comprising modified clay for preventing inflammation

Abstract

To provide an external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component.

What is claimed is: 
     
         1 - 15 . (canceled) 
     
     
         16 . An external skin agent comprising:
 1) montmorillonite, hectorite, or kaolinite modified by a compound having a quaternary amino group; and   2) a polymer or copolymer having a side chain including a structure of a saccharide residue, an amino acid residue, or a phospholipid residue.   
     
     
         17 . The external skin agent according to  claim 16 , wherein the compound having a quaternary amino group is dimethyl distearyl ammonium chloride. 
     
     
         18 . The external skin agent according to  claim 16 , wherein the saccharide residue, the amino acid residue, or the phospholipid residue is a glucosyloxyethyl group, a lysine residue, or a trimethylaminoethoxyphosphoethyl group. 
     
     
         19 . The external skin agent according  claim 16 , wherein the polymer or copolymer is a polymer or copolymer that is obtainable by addition polymerization of a vinyl monomer including one or two or more kinds of acrylic acids or methacrylic acids each represented by the following formula (X): 
       
         
           
           
               
               
           
         
         wherein R represents a hydrogen atom or a methyl group, and X represents a group including a structure of a saccharide residue, an amino acid residue, or a phospholipid residue. 
       
     
     
         20 . The external skin agent according to  claim 16 , wherein the polymer or copolymer is one or two or more kinds selected from the group consisting of polyglucosyloxyethyl methacrylate, polymethacryloyl lysine, polymethacryloyloxyethyl phosphorylcholine, a methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer, and a methacryloyloxyethyl phosphorylcholine-stearyl methacrylate copolymer. 
     
     
         21 . The external skin agent according to  claim 16 , further comprising a silicone. 
     
     
         22 . The external skin agent according to  claim 21 , wherein the silicone comprises at least three kinds of silicones consisting of a volatile silicone, a low-viscosity silicone, and a middle-viscosity silicone. 
     
     
         23 . The external skin agent according to  claim 21 , wherein the silicone comprises an alkylenoxide methylsiloxane copolymer, and a content of the alkylenoxide methylsiloxane copolymer is 0.1 to 10% by mass with respect to a total amount of the external skin agent. 
     
     
         24 . The external skin agent according to  claim 21 , wherein the silicone comprises:
 1) at least three kinds of dimethicones or phenylmethicones consisting of a volatile silicone, a low-viscosity silicone, and a middle-viscosity silicone; and   2) an alkylenoxide methylsiloxane copolymer.   
     
     
         25 . The external skin agent according to  claim 16 , further comprising a sucrose fatty acid ester. 
     
     
         26 . The external skin agent according to  claim 16 , further comprising one or two or more kinds of anti-inflammatory components selected from the group consisting of alcohol extract of Compositae Arctium lappa, alcohol extract of Araliaceae Panax Notoginseng, alcohol extract of Betulaceae  Betula maximowicziana , alcohol extract of Leguminosae  Sophora flavescens , alcohol extract of Lamiaceae  Salvia officinalis , alcohol extract of Juglandaceae  Engelhardtia chrysolepis , alcohol extract of Compositae  Achillea millefolium , alcohol extract of Lamiaceae  Rosmarinus officinalis , glycyrrhizinic acid and/or a salt thereof, glycyrrhetinic acid ester, ursolic acid and/or a salt thereof, ursolic acid ester, a glycoside of plant steroid (phytosterol), indomethacin, ketoprofen, ketotifen, bufexamac, dexamethasone, prednisolone, beclomethasone, betamethasone, hydrocortisol, and tacrolimus. 
     
     
         27 . The external skin agent according to  claim 16 , which is in a form of a water-in-oil emulsion. 
     
     
         28 . The external skin agent according to  claim 16 , which is used for alleviating or reducing the risk of atopic dermatitis.