Compounds and methods of treating neurological disorders

Abstract

Embodiments of the present disclosure provide for compositions including a compound, pharmaceutical compositions including the compound, methods of treatment of a disease or related condition (e.g., neurological disease on condition), methods of treatment using compositions or pharmaceutical compositions, and the like.

What is claimed is: 
     
         1 . A composition comprising: a compound having the following structure: 
       
         
           
           
               
               
           
         
         wherein X is CR 2 R 3 , NR 4 , O, S, SO, or SO 2 , 
         wherein R 1  is selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group, 
         wherein R 2  and R 3  are each independently selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group, and 
         wherein R 4  is selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group. 
       
     
     
         2 . The composition of  claim 1 , wherein X is CH 2 , NH, O, or 
       
         
           
           
               
               
           
         
       
     
     
         3 . The composition of  claim 1 , wherein R 1  is 
       
         
           
           
               
               
           
         
       
     
     
         4 . The composition of  claim 1 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         5 . The composition of  claim 1 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         6 . The composition of  claim 1 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         7 . The composition of  claim 1 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         8 . A pharmaceutical composition comprising a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier, to treat a disease, wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
         wherein X is CR 2 R 3 , NR 4 , O, S, SO, or SO 2 , 
         wherein R 1  is selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group, 
         wherein R 2  and R 3  are each independently selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group, and 
         wherein R 4  is selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group. 
       
     
     
         9 . The pharmaceutical composition of  claim 8 , wherein X is CH 2 , NH, O, or 
       
         
           
           
               
               
           
         
       
     
     
         10 . The pharmaceutical composition of  claim 8 , wherein R 1  is 
       
         
           
           
               
               
           
         
       
     
     
         11 . The pharmaceutical composition of  claim 8 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         12 . The pharmaceutical composition of  claim 8 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         13 . The pharmaceutical composition of  claim 8 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         14 . The pharmaceutical composition of  claim 8 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         15 . A method of treating a disease comprising: delivering to a subject in need thereof, a pharmaceutical composition, wherein the pharmaceutical composition includes a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier, to treat the disease, wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
         wherein X is CR 2 R 3 , NR 4 , O, S, SO, or SO 2 , 
         wherein R 1  is selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group, 
         wherein R 2  and R 3  are each independently selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group, and 
         wherein R 4  is selected from the group consisting of: H, a straight or branched, saturated or unsaturated, cyclic or acyclic, chiral or achiral hydrocarbyl group with up to 20 carbon atoms, where each hydrocarbyl group is optionally substituted with a hydroxyl group, an alkoxy group, an amino group, a substituted amino group, a thio group, an alkylthio group, a guanidine group, an ureido group, a heterocyclyl group, an aryl group, and a heteroaryl group. 
       
     
     
         16 . The method of  claim 15 , wherein X is CH 2 , NH, O, or 
       
         
           
           
               
               
           
         
       
       and wherein R 1  is 
       
         
           
           
               
               
           
         
       
     
     
         17 . The method of  claim 15 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         18 . The method of  claim 15 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         19 . The method of  claim 15 , wherein the compound has the following structure: 
       
         
           
           
               
               
           
         
       
     
     
         20 . The method of  claim 15 , wherein the compound has the following structure: