US2015320730A1PendingUtilityA1

GPBP-1 inhibition and its therapeutic use

Assignee: FIBROSTATIN S LPriority: Jul 2, 2012Filed: Jun 17, 2015Published: Nov 12, 2015

Est. expiryJul 2, 2032(~6 yrs left)· nominal 20-yr term from priority

Inventors:Juan Saus Francisco Ravert-Ros Fernando Revert Carmen Aguado-Velasco Ernesto Lopez-Pascual Alejandra María Pérez-Sastre Raül Blasco Héctor Pérez-Montoyo

A61K 31/704A61K 31/4406A61K 31/194A61K 45/06A61K 31/357A61K 31/4418A61K 31/216A61P 35/00A61P 43/00A61K 31/192

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Abstract

The present invention provides compositions including anti-tumor agents and inhibitors of Goodpasture antigen binding protein, p21, and ABCC7, and their use in treating cancer.

Claims

exact text as granted — not AI-modified

We claim: 
     
         1 . A pharmaceutical composition, comprising:
 (a) an antitumor drug or a pharmaceutically acceptable salt thereof;   (b) a compound of formula:   
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein:
 R is selected from N and CR 3 ; 
 R 1  is hydrogen or C 1 -C 6  alkoxy; 
 R 2  is C 1 -C 6  alkyl or halo(C 1 -C 6  alkyl); 
 R 3 , if present, is halogen, C 1 -C 6  alkyl, or halo(C 1 -C 6  alkyl); and 
 R 4  is H or C 1 -C 6  alkyl; and 
 (c) a pharmaceutically acceptable carrier.

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