Radioiodinated Fatty Acids

Abstract

The present invention provides novel radioiodinated fatty acids. Also provided are methods of preparation of said radioiodinated fatty acids from non-radioactive precursors, as well as radiopharmaceutical compositions comprising such radioiodinated fatty acids. The invention also provides in vivo imaging methods using the radioiodinated fatty acids.

1 - 18 . (canceled) 
     
     
         19 . A radioiodinated fatty acid of Formula (I): 
       
         
           
           
               
               
           
         
         where: 
         R 1  and R 2  are independently H or C 1-2  alkyl; 
         Y is a Y 2  group: 
       
       
         
           
           
               
               
           
         
         p and q are each independently integers of value 0 to 10 which are chosen such that [p+q] is in the range 10 to 16; 
         L 1  is a linker group of formula -(A) n - where n is an integer of value 0 to 3, and each A group is independently chosen from —CH 2 —, —O—, —S— and —C 6 H 4 — with the proviso that L 1  does not comprise —O—O—, —S—S— or —O—S— linkages; and 
         I* is a radioisotope of iodine. 
       
     
     
         20 . The radioiodinated fatty acid of  claim 19 , wherein I* is chosen from  123 I,  124 I or  131 I. 
     
     
         21 . The radioiodinated fatty acid of  claim 19 , where R 1  is CH 3  and R 2  is H. 
     
     
         22 . The radioiodinated fatty acid of  claim 19 , where L 1  is chosen from —CH 2 —, —O— and —S—. 
     
     
         23 . The radioiodinated fatty acid of  claim 19 , where n=0, and [p+q] is in the range 11 to 13. 
     
     
         24 . A radiopharmaceutical composition comprising an effective amount of the radioiodinated fatty acid of Formula (I) as defined in  claim 19 , together with a biocompatible carrier medium.