Use of statins for periodontaldisesae and bone regeneration

Abstract

The present invention discloses topical compositions comprising at least one statin as the main active compound for primary prevention or treatment of periodontal disease, for complementing standard treatment of periodontal disease, and for bone regeneration. The topical compositions are formulated for example, but not limited to, as toothpaste, mouthwash, tablets to dissolve in the mouth, elements or devices for intraoral slow-release of statins, dental floss, gel for being applied in dental trays, concentrated gel for irrigation of periodontal pockets, fluid (for example in blisters), powder, powder or liquid for preparing a solution, and gel. The present invention also discloses method for primary prevention or treatment of periodontal disease, for complementing standard treatment of periodontal disease, and for bone regeneration, comprising administering the topical compositions in the different formulations to a subject in need thereof.

1 . A topical composition for primary prevention or treatment of human or animal periodontal disease, oral lesions and mucosal wounds, wherein the composition comprise at least one statin. 
     
     
         2 . A topical composition for primary prevention or treatment according to  claim 1 , wherein the at least one statin is selected among lovastatin, pravastatin, simvastatin, fluvastatin, cerivastatin, and atorvastatin or pharmaceutical acceptable salts thereof. 
     
     
         3 . A topical composition for primary prevention or treatment according to  claim 2 , wherein the composition can also comprise one or more pharmaceutically acceptable carriers, vehicles, additives, excipients, solvents, adjuvants, dyes, flavourings, sweetenings, binders, emollients, fillers, lubricants, preservatives, diluents, thickeners, salts for influencing osmoting pressure, buffers, disintegrants, glidants, wettings, humectants, abrasive agents, surfactants, therapeutic agents (such as anticavities, antiplaque, agents for reducing hypersensitivity, and bleching agents), or combinations thereof. 
     
     
         4 . A topical composition for primary prevention or treatment according to  claim 3 , wherein the composition is formulated as toothpaste, mouthwash, tablets to dissolve in the mouth, elements or devices for intraoral slow-release of statins, and dental floss with at least one statin as the main active agent. 
     
     
         5 . A topical composition for primary prevention or treatment according to  claim 4 , wherein the composition is a toothpaste comprising 2% Atorvastatin. 
     
     
         6 . A topical composition for primary prevention or treatment according to  claim 2 , wherein the composition can be incorporated into beef, pork, lamb, chicken and/or turkey bones, cartilages or any substance the animal can chew, or into animal feed as cookies and pellet when the composition is used for treating animals. 
     
     
         7 . A topical composition for complementing standard treatment of human or animal periodontal disease, wherein the composition comprise at least one statin. 
     
     
         8 . A topical composition for complementing standard treatment according to  claim 7 , wherein the at least one statin is selected among lovastatin, pravastatin, simvastatin, fluvastatin, cerivastatin, and atorvastatin or pharmaceutical acceptable salts thereof. 
     
     
         9 . A topical composition for complementing standard treatment according to  claim 8 , wherein the composition can also comprise one or more pharmaceutically acceptable carriers, vehicles, additives, excipients, solvents, adjuvants, dyes, flavourings, sweetenings, binders, emollients, fillers, lubricants, preservatives, diluents, thickeners, salts for influencing osmoting pressure, buffers, disintegrants, glidants, wettings, humectants, abrasive agents, surfactants, therapeutic agents (such as anticavities, antiplaque, agents for reducing hypersensitivity, and bleching agents), or combinations thereof. 
     
     
         10 . A topical composition for complementing standard treatment according to  claim 9 , wherein the composition is formulated as toothpaste, mouthwash, tablets to dissolve in the mouth, elements or devices for intraoral slow-release of statins, and dental floss with at least one statin as the main active agent. 
     
     
         11 . A topical composition for complementing standard treatment according to  claim 10 , wherein the composition is a toothpaste comprising 2% Atorvastatin. 
     
     
         12 . A topical composition for complementing standard treatment according to  claim 8 , wherein the composition is formulated concentrated gel for being applied in dental trays and as concentrated gel for irrigation of periodontal pockets with at least one statin as the main active agent. 
     
     
         13 . A topical composition for complementing standard treatment according to  claim 7 , wherein the composition can be incorporated into beef, pork, lamb, chicken and/or turkey bones, cartilages or any substance the animal can chew, or into animal feed as cookies and pellet when the composition is used for treating animals. 
     
     
         14 . A topical composition for human or animal bone regeneration, wherein the composition comprise at least one statin. 
     
     
         15 . A topical composition for human or animal bone regeneration according to  claim 14 , wherein the at least one statin is selected among lovastatin, pravastatin, simvastatin, fluvastatin, cerivastatin, and atorvastatin or pharmaceutical acceptable salts thereof. 
     
     
         16 . A topical composition for human or animal bone regeneration according to  claim 15 , wherein the compositions is formulated as a concentrated composition, as fluid, as powder, as powder or liquid for preparing a solution, as gel, intended for direct application in bone defects or for application through a vehicle with graft materials, membranes and endo-osseous dental implants. 
     
     
         17 . A topical composition for human or animal bone regeneration according to  claim 14 , wherein the composition can be incorporated into beef, pork, lamb, chicken and/or turkey bones, cartilages or any substance the animal can chew, or into animal feed as cookies and pellet when the composition is used for treating animals. 
     
     
         18 . A method for primary prevention or treatment of human or animal periodontal disease, wherein the method comprises administering the topical composition according to  claim 1  to a subject in need thereof. 
     
     
         19 . A method for complementing standard treatment of human or animal periodontal disease, wherein the method comprises administering the topical composition according to  claim 7  to a subject in need thereof. 
     
     
         20 . A method for human or animal bone regeneration, wherein the method comprises administering the topical composition according to  claim 14  to a subject in need thereof.