US2015335672A1PendingUtilityA1

Treatment of Diseases Using Combination of Ultraviolet Blood Irradiation and Antibiotics

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Assignee: KUENSTNER JOHN TODDPriority: May 22, 2014Filed: May 22, 2015Published: Nov 26, 2015
Est. expiryMay 22, 2034(~7.8 yrs left)· nominal 20-yr term from priority
Inventors:John Todd Kuenstner
A61P 37/00A61P 29/00A61P 17/00A61P 17/06A61P 1/00A61P 21/00A61K 31/7052A61K 31/438A61K 31/498A61K 31/496A61K 31/07A61K 45/06A61N 2005/0661A61K 31/7048A61K 31/4164A61K 31/435A61M 2205/053A61N 5/0624A61K 31/59A61K 31/5383A61M 1/3681A61K 31/133
34
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Claims

Abstract

A method of and composition for treating a patient having Mycobacterium avium complex (MAC), and in one embodiment Mycobacterium avium subspecies paratuberculosis (MAP), causing one or more diseases, an embodiment of the method including administering to the patient an effective amount of one or more antibiotics and administering to the patient an effective amount of ultraviolet blood irradiation (UVBI) treatments, and an embodiment of the composition including an effective amount of one or more antibiotics and an effective amount of UVBI treated blood of the patient.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating a patient having  Mycobacterium avium  complex (MAC) causing one or more diseases, comprising:
 administering to the patient an effective amount of one or more antibiotics; and   administering to the patient an effective amount of ultraviolet blood irradiation (UVBI) treatment.   
     
     
         2 . The method of  claim 1 , wherein the one or more antibiotics comprise one or more of clarithromycin, azithromycin, rifampicin, rifabutin, clofazimine, ciprofloxacin, and metronidazole. 
     
     
         3 . The method of  claim 2 , further comprising administering to a patient at least one of Vitamin A and Vitamin D. 
     
     
         4 . The method of  claim 1 , wherein the one or more antibiotics comprise clarithromycin. 
     
     
         5 . The method of  claim 4 , wherein the one or more antibiotics further comprise at least one of rifabutin and rifampin. 
     
     
         6 . The method of  claim 5 , wherein the one or more antibiotics further comprise ethambutol. 
     
     
         7 . A method of treating a patient having  Mycobacterium avium  complex (MAC) causing one or more diseases, comprising:
 administering to a patient an effective amount of ultraviolet blood irradiation (UVBI) treatment; and   taking repeated measurements of MAC in the patient to demonstrate eradication of the MAC in the patient.   
     
     
         8 . A composition for treating a patient having  Mycobacterium avium  complex (MAC) causing one or more diseases, comprising:
 an effective amount of one or more antibiotics; and   an effective amount of ultraviolet blood irradiation (UVBI) treated blood of the patient.   
     
     
         9 . The composition of  claim 8 , wherein the one or more antibiotics comprises one or more of clarithromycin, azithromycin, rifampicin, rifabutin, clofazimine, ciprofloxacin, and metronidazole. 
     
     
         10 . The composition of  claim 9 , further comprising at least one of Vitamin A and Vitamin D. 
     
     
         11 . The composition of  claim 8 , wherein the one or more antibiotics comprise clarithromycin. 
     
     
         12 . The composition of  claim 11 , wherein the one or more antibiotics further comprise at least one of rifabutin and rifampin. 
     
     
         13 . The composition of  claim 12 , wherein the one or more antibiotics further comprise at least one of ethambutol. 
     
     
         14 . A composition for treating a patient having  Mycobacterium avium  complex (MAC) causing one or more diseases, comprising:
 an effective amount of ultraviolet blood irradiation (UVBI) treated blood of the patient.   
     
     
         15 . A method of treating a patient having  Mycobacterium avium  subspecies paratuberculosis (MAP) causing one or more autoimmune diseases, comprising:
 administering to the patient an effective amount of one or more antibiotics; and   administering to the patient an effective amount of ultraviolet blood irradiation (UVBI) treatment.   
     
     
         16 . The method of  claim 15 , wherein the one or more antibiotics comprise one or more of clarithromycin, azithromycin, rifampicin, rifabutin, clofazimine, ciprofloxacin, and metronidazole. 
     
     
         17 . The method of  claim 16 , further comprising administering to a patient at least one of Vitamin A and Vitamin D. 
     
     
         18 . The method of  claim 15 , wherein the one or more antibiotics comprise clarithromycin. 
     
     
         19 . The method of  claim 18 , wherein the one or more antibiotics further comprise at least one of rifabutin and rifampin. 
     
     
         20 . The method of  claim 19 , wherein the one or more antibiotics further comprise at least one of ciprofloxacin and levofloxacin. 
     
     
         21 . The method of  claim 15 , wherein the one or more autoimmune diseases comprise one or more of Crohn's disease, ulcerative colitis, type 1 diabetes mellitus, multiple sclerosis, complex regional pain syndrome, hypothyroidism, idiopathic thrombocytopenic purpura, lymphangiomatosis, sarcoidosis, Sjogren's disease, myasthenia gravis, scleroderma, systemic lupus erythematosis, psoriasis, and fibromyalgia. 
     
     
         22 . The method of  claim 15 , further comprising performing at least one of a blood culture for MAP, a Polymerase Chain Reaction test for MAP, and a test for MAP antibodies to confirm that the MAP has been eradicated in the patient. 
     
     
         23 . The method of  claim 15 , wherein the one or more autoimmune diseases comprise Crohn's disease. 
     
     
         24 . The method of  claim 23 , further comprising performing at least one of a blood culture for MAP, a Polymerase Chain Reaction test for MAP, and a test for MAP antibodies to confirm that the MAP causing the Crohn's disease has been eradicated in the patient. 
     
     
         25 . The method of  claim 23 , wherein the one or more antibiotics comprise clarithromycin and rifabutin. 
     
     
         26 . The method of  claim 25 , wherein the one or more antibiotics further comprise clofazimine, the clofazimine administered to the patient along with the other one or more antibiotics once the patient is in clinical remission for MAP. 
     
     
         27 . The method of  claim 15 , wherein the one or more autoimmune diseases comprise complex regional pain syndrome. 
     
     
         28 . The method of  claim 27 , wherein and the one or more antibiotics comprise clarithromycin, rifampin, ciprofloxacin, and clofazimine. 
     
     
         29 . The method of  claim 28 , further comprising administering to the patient at least one of Vitamin A and Vitamin D. 
     
     
         30 . The method of  claim 27 , further comprising performing at least one of a blood culture for MAP, a Polymerase Chain Reaction test for MAP, and a test for MAP antibodies to confirm that the MAP causing the complex regional pain syndrome has been eradicated in the patient. 
     
     
         31 . The method of  claim 15 , wherein the one or more autoimmune diseases comprise type 1 diabetes mellitus. 
     
     
         32 . A method of treating a patient having  Mycobacterium avium  subspecies paratuberculosis (MAP) causing one or more autoimmune diseases, comprising:
 administering to a patient an effective amount of ultraviolet blood irradiation (UVBI) treatment; and   taking repeated measurements of MAP in the patient to demonstrate eradication of the MAP in the patient.   
     
     
         33 . The method of  claim 32 , wherein the repeated measurements of MAP comprise taking one or more MAP blood cultures. 
     
     
         34 . The method of  claim 32 , wherein the repeated measurements of MAP comprise taking one or more tests for MAP antibodies. 
     
     
         35 . The method of  claim 32 , wherein the repeated measurements of MAP comprise taking one or more Polymerase Chain Reaction tests for MAP. 
     
     
         36 . A composition for treating a patient having  Mycobacterium avium  subspecies paratuberculosis (MAP) causing one or more autoimmune diseases, comprising:
 an effective amount of one or more antibiotics; and   an effective amount of ultraviolet blood irradiation (UVBI) treated blood of the patient.   
     
     
         37 . The composition of  claim 36 , wherein the one or more antibiotics comprise one or more of clarithromycin, azithromycin, rifampicin, rifabutin, clofazimine, ciprofloxacin, and metronidazole. 
     
     
         38 . The composition of  claim 37 , further comprising at least one of Vitamin A and Vitamin D. 
     
     
         39 . The composition of  claim 36 , wherein the one or more antibiotics comprise clarithromycin. 
     
     
         40 . The composition of  claim 39 , wherein the one or more antibiotics further comprise at least one of rifabutin and rifampin. 
     
     
         41 . The composition of  claim 40 , wherein the one or more antibiotics further comprise at least one of ciprofloxacin and levofloxacin. 
     
     
         42 . The composition of  claim 36 , wherein the one or more autoimmune diseases comprise one or more of Crohn's disease, ulcerative colitis, type 1 diabetes mellitus, multiple sclerosis, complex regional pain syndrome, hypothyroidism, idiopathic thrombocytopenic purpura, lymphangiomatosis, sarcoidosis, Sjogren's disease, myasthenia gravis, scleroderma, systemic lupus erythematosis, psoriasis, and fibromyalgia. 
     
     
         43 . The composition of  claim 36 , wherein the one or more autoimmune diseases comprise Crohn's disease. 
     
     
         44 . The composition of  claim 43 , wherein the one or more antibiotics comprise clarithromycin and rifabutin. 
     
     
         45 . The composition of  claim 44 , wherein the one or more antibiotics further comprise clofazimine. 
     
     
         46 . The composition of  claim 36 , wherein the one or more autoimmune diseases comprise complex regional pain syndrome. 
     
     
         47 . The composition of  claim 46 , wherein and the one or more antibiotics comprise clarithromycin, rifampin, ciprofloxacin, and clofazimine. 
     
     
         48 . The composition of  claim 47 , further comprising at least one of Vitamin A and Vitamin D. 
     
     
         49 . The composition of  claim 36 , wherein the one or more autoimmune diseases comprise type 1 diabetes mellitus. 
     
     
         50 . A composition for treating a patient having  Mycobacterium avium  subspecies paratuberculosis (MAP) causing one or more autoimmune diseases, comprising:
 an effective amount of ultraviolet blood irradiation (UVBI) treated blood of the patient.

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