Pharmaceutical compositions comprising gels and methods for fabricating thereof

Abstract

Pharmaceutical compositions are described, the compositions comprising a therapeutically effective quantity of an active component and a quantity of a sterile gel. Methods for fabricating the compositions and using them for ophthalmic or burn-treating applications are also described.

What is claimed is: 
     
         1 . An ophthalmological pharmaceutical composition or a pharmaceutical composition for treating burns, comprising:
 (a) a therapeutically effective quantity of an active component that is free of any of fluconazole, methazolamide, azitromycin, mitomycin, pilocarpine, povidone-iodine, dexamethasone, flurbiprofen, bromfenac, nepafenac, diclofenac, ketorolac, indomethacin, suprofen, norfloxacin, ciprofloxacin, antiseptics comprising the NH 4   +  cation, or pharmaceutically acceptable isomers, salts, hydrates or solvates thereof; and   (b) a quantity of a thermoreversible gel component that is free of any of chitosan, carbopol or polysorbate.   
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the gel component comprises a polymer that optionally includes cross-linked portions, the polymer being selected from the group consisting of poly(oxyethylene-co-oxypropylene) block copolymer, poly(N-isopropylacrylamide), poly(N-isopropylacrylamide-co-acrylic acid), poly(vinyl pyrrolidone), poly(4-vinylpyridine-co-ethylacrylate) block copolymer, poly(N-isopropylacrylamide-co-butyl methacrylate-co-ethylene glycol) block copolymer and combinations thereof. 
     
     
         3 . The pharmaceutical composition of  claim 2 , wherein the polymer is poly(oxyethylene-co-oxypropylene) block copolymer selected from the group consisting of Poloxamer 407®, Pluronic 127® and combinations thereof. 
     
     
         4 . The pharmaceutical composition of  claim 1 , wherein the composition is the ophthalmological composition in which the active component comprises at least one anesthetic, at least one non-steroid anti-inflammatory drug (NSAID), at least one anti-bacterial agent, at least one antiviral medicament, at least one antifungal medicament, at least one immunosuppressant, at least one corticosteroid, at least one keratopathy agent, at least one antioxidant, at least one vitamin, at least one medicament for treating glaucoma, at least one mydriatic agent, at least one antihistamine agent, at least one anti-VEGF medicament, at least one medicament for corneal pain treatment or at least one medicament for severe dry eye syndrome treatment. 
     
     
         5 . The pharmaceutical composition of  claim 4 , wherein the anesthetic is selected from the group consisting of lidocaine, tetracaine, proparacaine, procaine, dyclonine and combinations thereof. 
     
     
         6 . The pharmaceutical composition of  claim 4 , wherein the NSAID is selected from the group consisting of ketoprofen, ibuprofen and combinations thereof. 
     
     
         7 . The pharmaceutical composition of  claim 4 , wherein the anti-bacterial agent is a fluoroquinolone. 
     
     
         8 . The pharmaceutical composition of  claim 7 , wherein the anti-bacterial agent selected from the group consisting of moxifloxacin, gatifloxacin, nalidixic acid, oxolinic acid, piromidic acid, pipemidic acid, rosoxacin, enoxacin, fleroxacin, lomefloxacin, nadifloxacin, ofloxacin, pefloxacin, rufloxacin, balofloxacin, levofloxacin, pazufloxacin, sparfloxacin, tosufloxacin, clinafloxacin, gemifloxacin, sitafloxacin, prulifloxacin and combinations thereof. 
     
     
         9 . The pharmaceutical composition of  claim 4 , wherein the anti-bacterial agent is selected from the group consisting of vancomycin, teicoplanin, telavancin, decaplanin, ramoplanin, gentamicin, tobramycin, amikacin, cefuroxime, neomycin, neosporin, metronidazole, tinidazole, secnidazole, ornidazole, polymyxin, clindamycin, polyhexamethylene biguanide, chlorohexidine, bacitracin, chloramphenicol, erythromycin, natamycin, blephamide, sulfacetamide, sodium bicarbonate and combinations thereof. 
     
     
         10 . The pharmaceutical composition of  claim 4 , wherein the antiviral medicament is selected from the group consisting of idoxuridine, vidarabine and combinations thereof. 
     
     
         11 . The pharmaceutical composition of  claim 4 , wherein the antifungal medicament is ketoconazole. 
     
     
         12 . The pharmaceutical composition of  claim 4 , wherein the immunosuppressant is selected from the group consisting of tacrolimus, cyclosporine and combinations thereof. 
     
     
         13 . The pharmaceutical composition of  claim 4 , wherein the corticosteroid is selected from the group consisting of triamcinolone, betamethasone, fluorometholone, fluocinolone, prednisone, prednisolone, hydrocortisone and combinations thereof. 
     
     
         14 . The pharmaceutical composition of  claim 4 , wherein the keratopathy agent is ethylenediaminetetraacetic acid. 
     
     
         15 . The pharmaceutical composition of  claim 4 , wherein the antioxidant is selected from the group consisting of acetylcysteine, glutathione and combinations thereof. 
     
     
         16 . The pharmaceutical composition of  claim 4 , wherein the vitamin is riboflavin. 
     
     
         17 . The pharmaceutical composition of  claim 4 , wherein the medicament for treating glaucoma is selected from the group consisting of bimatoprost, latanoprost, travoprost, apraclonidine, brimonidine, dipivefrin, physostigmine, betoxolol, timolol, carbachol, acetazolamide and combinations thereof. 
     
     
         18 . The pharmaceutical composition of  claim 4 , wherein the mydriatic agent is selected from the group consisting of epinephrine, phenylephrine, tropicamide and combinations thereof. 
     
     
         19 . The pharmaceutical composition of  claim 4 , wherein the antihistamine agent is selected from the group consisting of olopatadine, ketotifen fumarate and combinations thereof. 
     
     
         20 . The pharmaceutical composition of  claim 4 , wherein the anti-VEGF medicament is selected from the group consisting of bevacizumab, pegaptanib, ranibizumab, lapatinib, sunitinib, sorafenib, axitinib, pazopanib and combinations thereof. 
     
     
         21 . The pharmaceutical composition of  claim 4 , wherein the medicament for corneal pain treatment is selected from the group consisting of nalbuphine, morphine and other opioids and combinations thereof. 
     
     
         22 . The pharmaceutical composition of  claim 4 , wherein the medicament for severe dry eye syndrome treatment is selected from the group consisting of albumin, plasminogen and combinations thereof. 
     
     
         23 . The pharmaceutical composition of  claim 4 , the composition consisting of a therapeutically effective quantity of at least one anti-bacterial agent, a therapeutically effective quantity of at least one corticosteroid and wherein the gel component is Poloxamer 407®. 
     
     
         24 . The pharmaceutical composition of  claim 4 , wherein the active component comprises triamcinolone and moxifloxacin and the gel component comprises Poloxamer 407®. 
     
     
         25 . The pharmaceutical composition of  claim 1 , wherein the composition is the composition for treating burns in which the active component comprises:
 (a) at least one anesthetic selected from the group consisting of lidocaine, tetracaine, proparacaine, procaine, dyclonine and combinations thereof;   (b) at least one NSAID,   (c) at least one anti-bacterial agent selected from the group consisting of vancomycin, teicoplanin, telavancin, decaplanin, ramoplanin, gentamicin, tobramycin, amikacin, cefuroxime, neomycin, mitomycin, neosporin, metronidazole, tinidazole, secnidazole, ornidazole, polymyxin, clindamycin, sulfa drugs, polyhexamethylene biguanide, chlorohexidine, bacitracin, chloramphenicol, erythromycin, natamycin, blephamide, sulfacetamide, sodium bicarbonate and a combination thereof,   (d) a quantity of an antifungal medicament ketoconazole;   (e) a quantity of a burn-healing agent misoprostol or   (f) at least one medicament for treating neuropathic pain selected from the group consisting of ketamine, morphine, fentanyl, pregabalin, carbamazepine, gabapentin, clonidine and combinations thereof.   
     
     
         26 . An ophthalmological pharmaceutical composition, comprising:
 (a) a therapeutically effective quantity of an corticosteroid selected from the group consisting of triamcinolone, dexamethasone, betamethasone, fluorometholone, fluocinolone, prednisone, prednisolone, hydrocortisone and combinations thereof;   (b) a therapeutically effective quantity of an anti-bacterial agent selected from the group consisting of moxifloxacin, gatifloxacin, nalidixic acid, oxolinic acid, piromidic acid, pipemidic acid, rosoxacin, enoxacin, fleroxacin, lomefloxacin, nadifloxacin, ofloxacin, pefloxacin, rufloxacin, balofloxacin, levofloxacin, pazufloxacin, sparfloxacin, tosufloxacin, clinafloxacin, gemifloxacin, sitafloxacin, prulifloxacin and combinations thereof; and   (c) a quantity of a thermoreversible gel component comprising a polymer selected from the group consisting of poly(oxyethylene-co-oxypropylene) block copolymer, poly(N-isopropylacrylamide), poly(N-isopropylacrylamide-co-acrylic acid), poly(vinyl pyrrolidone), poly(4-vinylpyridine-co-ethylacrylate) block copolymer, poly(N-isopropylacrylamide-co-butyl methacrylate-co-ethylene glycol) block copolymer and combinations thereof.   
     
     
         27 . The pharmaceutical composition of  claim 26 , wherein the corticosteroid is dexamethasone, the anti-bacterial agent is moxifloxacin and the polymer in the thermoreversible gel component is poly(oxyethylene-co-oxypropylene) block copolymer selected from the group consisting of Poloxamer 407®, Pluronic 127® and combinations thereof. 
     
     
         28 . The pharmaceutical composition of  claim 26 , further comprising a non-steroid anti-inflammatory drug selected from the group consisting of bromfenac, nepafenac, diclofenac, ketorolac and combinations thereof. 
     
     
         29 . The pharmaceutical composition of  claim 28 , wherein the corticosteroid is prednisone, the anti-bacterial agent is moxifloxacin, the polymer in the thermoreversible gel component is poly(oxyethylene-co-oxypropylene) block copolymer selected from the group consisting of Poloxamer 407®, Pluronic 127® and combinations thereof and a non-steroid anti-inflammatory drug is ketarolac.