Adjuvant compositions and methods of use

Abstract

This disclosure provides adjuvant compositions that are capable of modulating the immune response in a subject. These adjuvant compositions may also be used enhance the immunogenicity of antigens. Also provided are methods of making the adjuvant compositions as well as methods of using the adjuvant compositions.

1 - 29 . (canceled) 
     
     
         30 . A composition comprising:
 (a) a pharmaceutically acceptable vegetable oil selected from the group consisting of corn oil, olive oil, coconut oil, safflower oil, soybean oil and canola oil;   (b) a flavonoid; and   (c) a vitamin.   
     
     
         31 . The composition of  claim 30 , wherein said flavonoid is a catechin. 
     
     
         32 . The composition of  claim 31 , wherein said catechin is epigallocatechin gallate (EGCG). 
     
     
         33 . The composition of  claim 30 , wherein said composition comprises more than one flavonoid. 
     
     
         34 . The composition of  claim 30 , wherein said vitamin is selected from the group consisting of vitamin E, vitamin A, vitamin C, vitamin D and mixtures thereof. 
     
     
         35 . The composition of  claim 34 , wherein said vitamin is vitamin E. 
     
     
         36 . The composition of  claim 34 , wherein said vitamin is vitamin A. 
     
     
         37 . The composition of  claim 34 , wherein said vitamin is vitamin C. 
     
     
         38 . The composition of  claim 34 , wherein said vitamin is vitamin D. 
     
     
         39 . The composition of  claim 30 , further comprising an antigen. 
     
     
         40 . The composition of  claim 39 , wherein the antigen is influenza antigen. 
     
     
         41 . A method of modulating an immune response in a subject comprising administering the adjuvant composition of  claim 30  to said subject. 
     
     
         42 . The method of  claim 41 , wherein the subject is a mammal.