Bowel cleansing composition

Abstract

The present invention relates to a bowel cleansing preparation comprising, as a first cleansing ingredient, a certain sugar alcohol such as xylitol and sorbitol; as a second cleansing ingredient, ascorbic acid or a mixture of ascorbic acid and a salt of ascorbic acid; and aqueous solvent, wherein the concentration of said first cleansing ingredient is 10 g/L to 500 g/L based on the total preparation, the concentration of said second cleansing ingredient is 15 g/L to 500 g/L based on the total preparation, and the volume of said aqueous solvent is 0.1 L to 1.0 L. The bowel cleansing preparation has excellent cleansing efficacy, improved ease of administration and safety and can thus be used for bowel preparation prior to colonoscopy, therapeutic endoscopy, abdominal surgery and anal surgery for hemorrhoid as well as for the treatment and alleviation of diseases such as chronic and acute constipation.

1 . A bowel cleansing preparation comprising:
 as a first cleansing ingredient, at least one sugar alcohol selected from xylitol, sorbitol, glycerol, erythritol, threitol, arabitol, ribitol, mannitol, galactitol, fucitol, iditol, inositol, volemitol, isomalt, maltitol, lactitol, maltotriitol, maltotetraitol, and polyglycitol; as a second cleansing ingredient, ascorbic acid or a mixture of ascorbic acid and a salt of ascorbic acid; and an aqueous solvent,   wherein the concentration of said first cleansing ingredient is 10 g/L to 500 g/L based on the total preparation, the concentration of said second cleansing ingredient is 15 g/L to 500 g/L based on the total preparation, and the volume of said aqueous solvent is 0.1 L to 1.0 L.   
     
     
         2 . The bowel cleansing preparation of  claim 1 , wherein the preparation further comprises, as a third cleansing ingredient, bisacodyl, and the concentration of said third cleansing ingredient is 5 mg/L to 50 mg/L based on the total preparation. 
     
     
         3 . The bowel cleansing preparation of  claim 2 , wherein said third cleansing ingredient is incorporated in the form of a suspension. 
     
     
         4 . The bowel cleansing preparation of  claim 1 , wherein the preparation further comprises an anti-foaming agent, and the concentration of said anti-foaming agent is 100 mg/L to 2 g/L based on the total preparation, and said anti-foaming agent is simethicone. 
     
     
         5 . (canceled) 
     
     
         6 . The bowel cleansing preparation of  claim 1 , wherein the preparation further comprises a bicarbonate salt selected from sodium bicarbonate and potassium bicarbonate, and the concentration of said bicarbonate salt is 0.1 g/L to 10 g/L based on the total preparation in the case of sodium bicarbonate, and 0.1 g/L to 20 g/L based on the total preparation in the case of potassium bicarbonate. 
     
     
         7 . The bowel cleansing preparation of  claim 1 , wherein the preparation further comprises a gastrointestinal soother selected from ginger, peppermint, and chamomile, and the concentration of said gastrointestinal soother is 5 g/L to 50 g/L based on the total preparation. 
     
     
         8 . The bowel cleansing preparation of  claim 1 , wherein said first cleansing ingredient is xylitol. 
     
     
         9 . The bowel cleansing preparation of  claim 1 , wherein said first cleansing ingredient is sorbitol. 
     
     
         10 . The bowel cleansing preparation of  claim 1 , wherein said first cleansing ingredient is a mixture of xylitol and sorbitol. 
     
     
         11 . The bowel cleansing preparation of  claim 1 , wherein, when said second cleansing ingredient is a mixture of ascorbic acid and a salt of ascorbic acid, the mass ratio of ascorbic acid to the salt of ascorbic acid ranges from 99:1 to 60:40. 
     
     
         12 . The bowel cleansing preparation of  claim 1 , wherein said aqueous solvent is water, carbonated water, alkaline ionized water or a beverage. 
     
     
         13 . The bowel cleansing preparation of  claim 1 , wherein said aqueous solvent is carbonated water. 
     
     
         14 . The bowel cleansing preparation of  claim 1 , wherein the concentration of said first cleansing ingredient is 50 g/L to 150 g/L based on the total preparation. 
     
     
         15 . The bowel cleansing preparation of  claim 1 , wherein the concentration of said second cleansing ingredient is 30 g/L to 200 g/L based on the total preparation. 
     
     
         16 . The bowel cleansing preparation of  claim 1 , wherein the volume of said aqueous solvent is 0.3 L to 0.7 L. 
     
     
         17 . The bowel cleansing preparation of  claim 1 , wherein the preparation is a one-part product. 
     
     
         18 . The bowel cleansing preparation of  claim 1 , wherein the preparation is a two-part product. 
     
     
         19 . The bowel cleansing preparation of  claim 18 , wherein the preparation is formulated into a two-part product consisting of (i) a package containing a highly concentrated solution formulated by mixing all ingredients in 0.05 L to 0.2 L of total volume of said aqueous solvent and (ii) a separate package containing the remaining amount of the aqueous solvent that is its total volume minus the volume used in formulating the highly concentrated solution.