US2015343019A1PendingUtilityA1

Recombinant lubricin molecules and uses thereof

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Assignee: WYETH LLCPriority: Aug 14, 2003Filed: Feb 5, 2015Published: Dec 3, 2015
Est. expiryAug 14, 2023(expired)· nominal 20-yr term from priority
Inventors:Carl Ralph FlanneryChristopher John CorcoranBethany FreemanLisa Collins-Racie
A61P 35/00A61P 9/00A61P 43/00A61P 29/00A61P 25/04A61K 38/1709C07K 14/47A61K 45/06A61P 19/02C07K 14/475A61P 19/00A61K 38/00A61P 11/00A61K 38/18A61K 38/19A61P 19/04A61P 21/00C07K 16/18A61K 38/17C07K 14/435
54
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Claims

Abstract

Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.

Claims

exact text as granted — not AI-modified
1 .- 10 . (canceled) 
     
     
         11 . An isolated protein comprising the amino acid sequence of SEQ ID NO: 15. 
     
     
         12 - 32 . (canceled) 
     
     
         33 . The protein of  claim 11 , wherein the protein is O-linked to β-(1-3)-Gal-GalNac. 
     
     
         34 . A composition comprising a therapeutically effective amount of a protein of  claim 33  in a pharmaceutically acceptable carrier. 
     
     
         35 . The composition of  claim 34 , additionally comprising hyaluronan or hylan. 
     
     
         36 . The composition of  claim 34 , wherein the composition is formulated for injection. 
     
     
         37 . The composition of  claim 34 , wherein the composition is encapsulated. 
     
     
         38 . The composition of  claim 37 , wherein the composition is encapsulated in an implantable drug delivery matrix. 
     
     
         39 . The composition of  claim 34 , wherein the composition further comprises a local anesthetic. 
     
     
         40 . The composition of  claim 34 , wherein the composition further comprises a cytokine. 
     
     
         41 . The composition of  claim 34 , wherein the composition further comprises a lymphokine. 
     
     
         42 . The composition of  claim 34 , wherein the composition further comprises a thrombolytic factor. 
     
     
         43 . The composition of  claim 34 , wherein the composition further comprises an antithrombolytic factor. 
     
     
         44 . The composition of  claim 34 , wherein the composition further comprises an anti-inflammatory agent. 
     
     
         45 . The composition of  claim 34 , wherein the composition further comprises an antibiotic. 
     
     
         46 . The composition of  claim 34 , wherein the composition further comprises a growth factor.

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