Methods of treatment of fibrosis and cancers

Abstract

The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethyl-methyloxyphenyl]prop-2-en-1-one for treating fibrotic diseases and cancers.

1 . Compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one for use in a method for the treatment or prevention of fibrotic diseases, wherein the fibrotic disease is not liver fibrosis, or for the treatment or prevention of a tyrosine kinase related cancer. 
     
     
         2 . The compound for use according to  claim 1 , wherein the fibrotic disease is a lung, heart, muscle, skin, soft tissue, bone marrow, intestinal, and joint fibrosis. 
     
     
         3 . The compound for use according to  claim 1 , wherein the fibrotic disease is pulmonary fibrosis, idiopathic pulmonary fibrosis, cystic fibrosis, endomyocardial fibrosis, mediastinal fibrosis, myelofibrosis, retroperitoneal fibrosis, progressive massive fibrosis, nephrogenic systemic fibrosis, Crohn's Disease, keloid, old myocardial infarction, scleroderma/systemic sclerosis, arthrofibrosis or an adhesive capsulitis. 
     
     
         4 . The compound for use according to  claim 1 , wherein the tyrosine kinase related-cancer is a PDGFR, -VEGFR- or KIT-related cancer. 
     
     
         5 . The compound for use according to  claim 1 , wherein the cancer is a renal cell carcinoma, gastrointestinal stromal tumor (GIST), gastric cancer, menigioma associated with neurofibromatosis, pancreatic neuroendocrine tumors, pancreatic exocrine tumors, leukemia, myeloproliferative/myelodisplastic diseases, mastocytosis, dermatofibrosarcoma, solid tumors including breast, lung, thyroid or colorectal cancer or a prostate cancer. 
     
     
         6 . Compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one for use in a method for the curative treatment of a liver cancer. 
     
     
         7 . The compound for use according to  claim 6 , wherein the liver cancer is a hepatocellular carcinoma. 
     
     
         8 . Compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one for use in the inhibition of proliferation and/or activation of cells responsible for the production of collagen fibers and/or responsible for the production of the extracellular matrix. 
     
     
         9 . Compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one for use in promoting apoptosis of cells responsible for the production of collagen fibers and/or responsible for the production of the extracellular matrix.