Conjugate of a fragment of a cellular wall of a bacterium and a mucopolysaccharidic carrier, and uses in medicine thereof

Abstract

The present invention relates in one aspect to a conjugate of a mucopolysaccharide or mucopolysaccharidic fraction and a cellular wall fragment of a bacterium belonging to the Corynebacterium genus, and in particular to the Corynebacterium granulosum species, also named P40. The conjugate of the invention is applied to medicine, in particular for topical treatment of infections, dermatological affections, such as psoriasis, acne, allergic reactions, such as rashes and eczema, and in vaginal mucosae affections.

1 . A conjugate of a fragment of a cellular wall of  Corynebacterium granulosum  P40 and a physiologically acceptable carrier, wherein the physiologically acceptable carrier comprises a mucopolysaccharide or a mucopolysaccharidic fraction. 
     
     
         2 . Conjugate according to  claim 1 , wherein the physiologically acceptable mucopolysaccharide or mucopolysaccharidic fraction is selected from hyaluronic acid, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate, heparan sulfate, heparin, keratan-sulfate and mixtures thereof. 
     
     
         3 . The conjugate according to  claim 1 , wherein the fragment of a cellular wall of  Corynebacterium granulosum  P40 is an insoluble fraction isolated from a delipidated cellular wall of  Corynebacterium granulosum.    
     
     
         4 . A medical device or medicine comprising the conjugate according to  claim 1 . 
     
     
         5 . A method for modulating the immune or antibody response of skin and/or mucosa comprising: applying on the skin or mucosa an effective amount of the conjugate according to  claim 1 . 
     
     
         6 . A method for the prevention or treatment of dermatological bacterial, viral or fungal infections comprising: administering an effective amount of the conjugate according to  claim 1 . 
     
     
         7 . A method for the topical treatment of dermatological affections or disorders comprising: applying on skin an effective amount of the conjugate according to  claim 1 . 
     
     
         8 . A method for the prevention or treatment of allergic skin disorders or affections comprising: applying on the skin an effective amount of the conjugate according to  claim 1 . 
     
     
         9 . A method for the prevention or treatment of mucosal disorders or affections comprising: applying on a mucosa an affective amount of the conjugate according to  claim 1 . 
     
     
         10 . The method of  claim 9 , wherein the mucosa is vaginal mucosa. 
     
     
         11 . A composition for topical use comprising the conjugate according to  claim 1  and a physiologically acceptable excipient. 
     
     
         12 . (canceled)