Quinolinyl glucagon receptor modulators

Abstract

The present invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , A 1 , A 2 , A 3 , B 1 , B 2 , B 3 and B 4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.

We claim: 
     
         1 . A compound of structure 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         2 . A pharmaceutical composition comprising the compound of  claim 1  and at least one pharmaceutically acceptable excipient, diluent, or adjuvant. 
     
     
         3 . A method of treating Type II diabetes in a patient comprising administering to the patient in need of such treatment a therapeutically effective amount of the compound of  claim 1 .