US2015361047A1PendingUtilityA1

Process for the Preparation of Cycloheptapyridine CGRP Receptor Antagonists

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Assignee: BRISTOL MYERS SQUIBB COPriority: Oct 12, 2010Filed: Aug 24, 2015Published: Dec 17, 2015
Est. expiryOct 12, 2030(~4.2 yrs left)· nominal 20-yr term from priority
Inventors:David K. LeahyYu FanCollin ChanLopa V. DesaiSunil S. PatelMasano Sugiyama
C07F 7/1804C07D 471/04C07D 221/04C07F 7/1856
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Claims

Abstract

The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . A compound of formula II, or a salt thereof, where Ar 1  is phenyl substituted with 0-3 substituents selected from the group consisting of cyano, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, and alkylSO 2  and R 1  is hydrogen or trialkylsilyl, alkoxy, alkylcarbonyl, benzyl, benzoyl, and pivaloyl. 
       
         
           
           
               
               
           
         
       
     
     
         2 . The compound of  claim 1  where Ar 1  is 2,3-difluorophenyl and R 1  is hydrogen or a salt thereof. 
     
     
         3 . The compound of  claim 2  which is the dihydrochloride salt. 
     
     
         4 . The compound of  claim 1  where Ar 1  is 2,3-difluorophenyl and R 1  is triisopropylsilyl or a salt thereof. 
     
     
         5 . The compound of  claim 4  which is the dihydrochloride salt.

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