Method for preventing and/or treating infections, colonisations, or illnesses related to staphylococcus aureus, pseudomonas aeruginosa, streptococcus pyogenes, enterococcus faecium, enterobacter cloacae, proteus mirabilis, bacteroides fragilis, staphylococcus epidermidis, propionibacterium acnes, candida albicans and/or malassezia furfur

Abstract

The subject matter of the present invention is a bacterium or a mixture of bacteria having an antagonistic activity with respect to strains of S. aureus, P. aeruginosa, Streptococcus pyogenes, Enterococcus faecium, Enterobacter cloacae, Proteus mirabilis, Bacteroides fragilis, Staphylococcus epidermidis, Propionibacterium acnes, Candida albicans and/or Malassezia furfur as well as the use thereof in the treatment and/or prevention of infections or colonizations related to those pathogens. The invention pertains to care products containing one or more non-pathogenic antagonistic strains intended to prevent and/or treat infections or colonizations on skin, wounds, mucous membranes and appendages.

1 . A bacterium chosen from  Lactobacillus saniviri  registered on Jul. 12, 2012, at the CNCM under No. I-4650,  Lactobacillus salivarius  registered on Jul. 12, 2012, at the CNCM respectively under Nos. I-4651, I-4652 and I-4653,  Streptococcus mitis  registered on Jul. 12, 2012, under No. CNCM I-4654 and  Lactobacillus pentosus  or  plantarum  registered on Jul. 12, 2012, under No. CNCM I-4655. 
     
     
         2 . The bacterium as claimed in  claim 1 , for use as an active ingredient, a medical device, a cosmetic or a food supplement or as an active ingredient in a medicament, in a medical device, in a cosmetic or in a food supplement. 
     
     
         3 . The bacterium as claimed in  claim 1 , for use in preventing and/or treating an infection and/or a colonization related to at least one bacterium or one yeast chosen from  S. aureus, P. aeruginosa, Streptococcus pyogenes, Enterococcus faecium, Enterobacter cloacae, Proteus mirabilis, Bacteroides fragilis, Staphylococcus epidermidis, Propionibacterium acnes, Candida albicans  and  Malassezia furfur.    
     
     
         4 . The bacterium as claimed in  claim 1 , for use in preventing and/or treating an infection and/or a colonization related to  S. aureus  and/or  P. aeruginosa.    
     
     
         5 . The bacterium as claimed in  claim 1 , for use as an immunomodulator. 
     
     
         6 . The bacterium as claimed in  claim 1 , characterized in that it is applied to the skin, wounds, mucosae and/or superficial body growths. 
     
     
         7 . The bacterium as claimed in  claim 3 , characterized in that the infection and/or the colonization concern the skin, a wound, in particular a wound chosen from diabetic foot ulcers, leg ulcers of arterial origin, leg ulcers of venous origin, bedsores, whitlow, acute wounds, traumatic wounds and post-operative wounds. 
     
     
         8 . A composition comprising at least one bacterium as claimed in  claim 1 . 
     
     
         9 . The composition as claimed in  claim 8 , characterized in that it also comprises at least one compound chosen from probiotics, prebiotics and yeasts. 
     
     
         10 . The composition as claimed in  claim 8 , characterized in that it also comprises at least one active agent chosen from antifungal agents, painkillers, anti-inflammatories, active agents which promote healing, moisturizing agents, keratolytic agents, restructuring agents and anesthetics. 
     
     
         11 . The composition as claimed in  claim 8 , characterized in that it is suitable for topical, oral or parenteral application. 
     
     
         12 . The composition as claimed in  claim 8 , characterized in that it is in the form of a salve, a cream, a milk, an ointment, a powder, an impregnated pad, a syndet, a wipe, a solution, a gel, a spray, a foam, a suspension, a lotion, a stick, a shampoo, a washing base, a tablet, a gel capsule, a food product or an injectable solution. 
     
     
         13 . The composition as claimed in  claim 8 , characterized in that the bacterium is present in an amount of between 10 3  and 10 12  bacteria. 
     
     
         14 . The composition as claimed in  claim 8 , characterized in that the bacterium is present in the form of an inactivated cell, a living cell or a cell lysate, which may be encapsulated or nonencapsulated, immobilized or nonimmobilized and lyophilized or nonlyophilized. 
     
     
         15 . A dressing comprising at least one bacterium as claimed in  claim 1 .