US2015374715A1PendingUtilityA1

Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection

Assignee: GEMMUS PHARMA INCPriority: Nov 16, 2006Filed: Feb 27, 2015Published: Dec 31, 2015
Est. expiryNov 16, 2026(~0.3 yrs left)· nominal 20-yr term from priority
A61P 31/16A61P 43/00A61P 29/00A61K 31/7012A61K 31/215A61K 31/343A61K 31/5585A61K 31/5578A61K 47/6951A61P 11/00A61K 31/5575A61K 47/48969
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Claims

Abstract

The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof.

Claims

exact text as granted — not AI-modified
1 - 20 . (canceled) 
     
     
         21 : A method of inhibiting the release of overstimulated cytokines and/or chemokines in a subject, said method comprising administering to a subject in need thereof an amount of beraprost effective to inhibit the release of overstimulated cytokines and/or chemokines. 
     
     
         22 : The method of  claim 21 , wherein said cytokines and/or chemokines are inflammatory cytokines or chemokines. 
     
     
         23 : The method of  claim 21 , wherein the overstimulated cytokines comprise TNFα. 
     
     
         24 : The method of  claim 21 , wherein the overstimulated cytokines comprise IFN-gamma. 
     
     
         25 : The method of  claim 21 , wherein said beraprost is a pharmaceutically acceptable salt or cyclodextrin clathrate.

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