Formulations and compositions of vitamin d analogs for treating and preventing cancer and other diseases

Abstract

This invention is for formulations of analogs of the non-toxic and inert Vitamin D3, its non-toxic and mostly inert pre-hormone and its toxic and biologically active hormone, and for using these formulations for preventing and treating certain cancers such as breast, prostate, ovarian, kidney, renal and other cancers, Vitamin D deficiency, autoimmune disease such as Multiple Sclerosis, hypertension, osteoporosis, bone diseases, rickets, psoriasis and infectious diseases. This invention also discloses compositions of the analogs of the non-toxic and inert Vitamin D3 and the non-toxic and mostly inert Vitamin D3 pre-hormone.

1 . A method of treating a disease responsive to Vitamin D3 or Vitamin D3 analog comprising the steps of:
 a. Providing a medicament having a plurality of nanosomes having at least one bilayer of phospholipid in which a Vitamin D3 or Vitamin D3 analog is distributed; and   b. Administering an amount of medicament having an effective amount of Vitamin D3 or Vitamin D3 analog to treat such disease.   
     
     
         2 . The method of  claim 1  wherein said disease is selected from the group consisting of cancer, Vitamin D deficiency, autoimmune disease, hypertension, osteoporosis, bone disease, psoriasis and infectious disease. 
     
     
         3 . The method of  claim 1  wherein said Vitamin D 3  analog is selected from the group consisting of the bromoacetate derivative (1α,25-dihydroxyvitamin D 3 -3-bromoacetate [1,25(OH) 2 D 3 -3-BE]) of the active Vitamin D 3  hormone (AMPI-109), the bromoacetate derivative (25-hydroxyvitamin D 3 -3-bromoacetate[25-OH-D 3 -3-BE]) of the non-toxic pre-hormonal form of Vitamin D 3  (AMPI-105), the epoxide derivative (25-hydroxyvitamin D 3 -3-epoxide [25-OH-D 3 -3-EPO]) of the non-toxic pre-hormonal form of Vitamin D 3  (AMPI-106), the epoxide derivative (Vitamin D 3 -3-epoxide [D 3 -3-EPO]) of the non-toxic and inert Vitamin D 3  (AMPI-107) and the bromoacetate derivative (Vitamin D 3 -3-bromoacetate [D 3 -3-BE]) of the non-toxic and inert Vitamin D 3  (AMPI-108). 
     
     
         4 . A method of treating a disease responsive to Vitamin D3 or Vitamin D3 analog comprising the steps of:
 a. Providing a gel capsule having a gelatin outer layer defining an inner volume and having an oil base contained in said inner volume, and further comprising Vitamin D3 or Vitamin D3 analog dissolved in said oil base; and   b. Administering an effective amount of Vitamin D3 analog by ingesting one or more gel capsules.   
     
     
         5 . The method of  claim 4  wherein said disease is selected from the group consisting of cancer, Vitamin D deficiency, autoimmune disease, hypertension, osteoporosis, bone disease, psoriasis and infectious disease. 
     
     
         6 . The method of  claim 4  wherein said Vitamin D 3  analog is selected from the group consisting of the bromoacetate derivative (1α,25-dihydroxyvitamin D 3 -3-bromoacetate [1,25(OH) 2 D 3 -3-BE]) of the active Vitamin D 3  hormone (AMPI-109), the bromoacetate derivative (25-hydroxyvitamin D 3 -3-bromoacetate[25-OH-D 3 -3-BE]) of the non-toxic pre-hormonal form of Vitamin D 3  (AMPI-105), the epoxide derivative (25-hydroxyvitamin D 3 -3-epoxide [25-OH-D 3 -3-EPO]) of the non-toxic pre-hormonal form of Vitamin D 3  (AMPI-106), the epoxide derivative (Vitamin D 3 -3-epoxide [D 3 -3-EPO]) of the non-toxic and inert Vitamin D 3  (AMPI-107) and the bromoacetate derivative (Vitamin D 3 -3-bromoacetate [D 3 -3-BE]) of the non-toxic and inert Vitamin D 3  (AMPI-108). 
     
     
         7 . As a composition of matter, a composition comprising an analog of the non-toxic and inert Vitamin D 3  selected from the group consisting of Vitamin D 3 -3-epoxide [D 3 -3-EPO] and Vitamin D 3 -3-bromoacetate [D 3 -3-BE]. 
     
     
         8 . A composition of  claim 7  where such Vitamin D analog is Vitamin D 3 -3-epoxide [D 3 -3-EPO]. 
     
     
         9 . A composition of  claim 7  where such Vitamin D analog is the Vitamin D 3 -3-bromoacetate [D 3 -3-BE].