Use of chitosans to increase nail growth rate

Abstract

The present invention is directed to the use of chitosan, a chitosan derivative or a physiologically acceptable salt thereof, to increase nail growth rate. The invention is further directed to the use of chitosans to accelerate nail growth rate during treatment of nail illnesses, nail dystrophy or other nail conditions, in order to shorten considerably the specific treatments of said nail illnesses, nail dystrophy or other nail conditions.

1 . A method for accelerating the nail growth rate of healthy nails during treatment of a nail illness consisting of applying to a nail, a topical formulation consisting of chitosan, and/or a water soluble chitosan derivative selected from hydroxyalkyl chitosan and carboxyalkyl chitosan, and/or a physiologically acceptable salt thereof in combination with one or more antimycotic agents in an amount effective to accelerate the growth rate of the nail, and compatible excipients and pharmaceutically acceptable carriers. 
     
     
         2 . The method of  claim 1 , wherein the topical formulation is applied to the nail for at least 24 weeks. 
     
     
         3 . The method of  claim 1 , wherein the topical formulation is applied to the nail for at least 36 weeks. 
     
     
         4 . The method of  claim 1 , wherein the topical formulation is applied to the nail for at least 48 weeks. 
     
     
         5 . The method of  claim 1 , wherein the nail illness is a nail infection. 
     
     
         6 . The method of  claim 1 , wherein the water soluble chitosan derivative exhibits a molecular weight greater than 50,000 Daltons. 
     
     
         7 . The method of  claim 1 , wherein the water soluble chitosan derivative exhibits a molecular weight from 100,000 to 500,000 Daltons. 
     
     
         8 . The method of  claim 1 , wherein the hydroxyalkyl chitosan is hydroxypropyl chitosan.  
     
     
         9 . The method of  claim 1 , wherein the topical formulation comprises chitosan, a water soluble chitosan derivative selected from hydroxyalkyl chitosan and carboxyalkyl chitosan, and/or a physiologically acceptable salt thereof, in an amount from 0.1 to 10 wt. % with respect to the total weight of the topical formulation. 
     
     
         10 . The method of  claim 9 , wherein the topical formulation comprises chitosan, a water soluble chitosan derivative selected from hydroxyalkyl chitosan and carboxyalkyl chitosan, and/or a physiologically acceptable salt thereof, in an amount from 0.2 to 5 wt. % with respect to the total weight of the topical formulation. 
     
     
         11 . The method of  claim 10 , wherein the topical formulation comprises chitosan, a water soluble chitosan derivative selected from hydroxyalkyl chitosan and carboxyalkyl chitosan, and/or a physiologically acceptable salt thereof, in an amount from 0.3 to 2 wt. % with respect to the total weight of the topical formulation. 
     
     
         12 . The method of  claim 1 , wherein the topical formulation is in the form of a nail lacquer, a spray, a cream, an ointment, a gel, a lotion or a foam.