Natural lipids containing non-oxidizable fatty acids

Abstract

Provided herein is technology relating to natural lipids containing non-β-oxidizable fatty acids and particularly, but not exclusively, to compositions and methods related to the production and use of natural lipids containing non-β-oxidizable fatty acids.

1 - 71 . (canceled) 
     
     
         78 . A structured phospholipid composition comprising phospholipid molecules of the following structure: 
       
         
           
           
               
               
           
         
       
       wherein one of R1 and R2 is a non-beta-oxidizable fatty acid analogue moiety and the other of R1 and R2 is a bioactive fatty acid moiety selected from the group consisting of an omega-3 fatty acid moiety, on omega-6 fatty acid moiety, a polyunsaturated fatty acid moiety, a conjugated linoleic fatty acid moiety, and combinations thereof. 
     
     
         79 . The structured phospholipid composition of  claim 78 , wherein said composition comprises greater than 10%, 20%, 30%, 40%, 50%, 80%, 90% or 99% on a molar basis of said non-beta-oxidizable fatty acid analogue moiety at position R1. 
     
     
         80 . The structured phospholipid composition of  claim 78 , wherein said composition comprises greater than 50%, 80%, 90% or 99% on a molar basis of said non-beta-oxidizable fatty acid analogue moiety at position R2. 
     
     
         81 . The structured phospholipid composition of  claim 78 , comprising greater than about 50%, 80%, 90% or 99% on a molar basis of said bioactive fatty acid moieties or combinations thereof at position R2. 
     
     
         82 . The structured phospholipid composition of  claim 78 , comprising greater than about 50%, 80%, 90% or 99% on a molar basis of said bioactive fatty acid moiety at position R1. 
     
     
         83 . The structured phospholipid composition of  claim 81 , wherein said bioactive fatty acid moiety is selected from the group consisting of EPA, DHA and a combination thereof. 
     
     
         84 . The structured phospholipid composition of  claim 81 , wherein said bioactive fatty acid moiety is EPA. 
     
     
         85 . The structured phospholipid composition of  claim 81 , wherein said bioactive fatty acid moiety is DHA. 
     
     
         86 . The structured phospholipid composition of  claim 81 , wherein said bioactive fatty acid moiety is conjugated linoleic acid. 
     
     
         87 - 111 . (canceled) 
     
     
         112 . A pharmaceutical composition comprising the structured lipid of  claim 78  and a pharmaceutically acceptable carrier. 
     
     
         113 . The pharmaceutical composition of  claim 112  wherein the structured lipid comprises TTA. 
     
     
         114 . The pharmaceutical composition of  claim 112  wherein structured lipid comprises an ether link between a lipid tail and a lipid headgroup. 
     
     
         115 . The pharmaceutical composition according to  claim 112 , admixed with at least one of a pharmaceutically acceptable carrier, diluent, excipient, or adjuvant. 
     
     
         116 - 130 . (canceled)