Method for electronic biological sample analysis

Abstract

A biological sample analysis device includes a casing that encloses a biological sample delivery system hydraulically coupled to a sensor, wherein the sensor includes a plurality of Graphene transistors and each transistor covalently bonds with a biomarker causing the electrical properties of the transistor to measurably change when the biomarker is exposed to corresponding antibodies within an infected biological sample.

What is claimed is: 
     
         1 . The method for electronic biological sample analysis comprising:
 introducing a biological sample to a sample chamber, the sample chamber comprising a sensor configured to output a first current range when the sample sensor is exposed to a sterile liquid and a second current range when the sensor is exposed to predetermined antibodies;   applying a voltage to the sensor;   measuring a current output from the sensor; and   determining if the current output is within the first current range or the second current range.   
     
     
         2 . The method of  claim 1 , wherein the sensor comprises one or more Graphene transistors and applying a voltage to the sensor comprises applying a drain-source voltage and a gate-source bias. 
     
     
         3 . The method of  claim 1 , wherein the biological sample is blood, serum, urine, or cerebral fluid. 
     
     
         4 . The method of  claim 1 , wherein the measuring the current output from the sensor is performed at regular intervals. 
     
     
         5 . The method of  claim 3 , further comprising plotting the current output over time and analyzing a trend. 
     
     
         6 . The method of  claim 1 , further comprising flushing the biological sample from the sample chamber with a sterile solution. 
     
     
         7 . The method of  claim 6 , further comprising re-introducing the biological sample to the sample chamber. 
     
     
         8 . The method of  claim 7 , further comprising repeating for a plurality of cycles the flushing the biological sample from the sample chamber with a sterile solution and re-introducing the biological sample to the sample chamber and calculating a statistical average current output when the biological sample is in the sample chamber. 
     
     
         9 . The method of  claim 1 , further comprising returning a “test positive” signal if the current output is within the second current range. 
     
     
         10 . The method for electronic biological sample analysis comprising:
 introducing a biological sample to a sample chamber, the sample chamber including a sensor comprising one or more Graphene transistors, the sensor configured to output a first current range when the sample sensor is exposed to a sterile liquid and a second current range when the sensor is exposed to predetermined antibodies;   applying a voltage to the sensor;   measuring a current output from the sensor;   determining if the current output is within the first current range or the second current range; and   returning a “test positive” signal if the current output is within the second current range.   
     
     
         11 . The method of  claim 10 , wherein applying a voltage to the sensor comprises applying a drain-source voltage and a gate-source bias. 
     
     
         12 . The method of  claim 10 , wherein the biological sample is blood, serum, urine, or cerebral fluid. 
     
     
         13 . The method of  claim 10 , wherein measuring the current output from the sensor is performed at regular intervals. 
     
     
         14 . The method of  claim 13 , further comprising plotting the current output over time and analyzing a trend. 
     
     
         15 . The method of  claim 10 , further comprising flushing the biological sample from the sample chamber with a sterile solution. 
     
     
         16 . The method of  claim 15 , further comprising re-introducing the biological sample to the sample chamber. 
     
     
         17 . The method of  claim 16 , further comprising repeating for a plurality of cycles the flushing the biological sample from the sample chamber with a sterile solution and re-introducing the biological sample to the sample chamber and calculating a statistical average current output when the biological sample is in the sample chamber.