Rubber toughened bioresorbable polymer peripheral scaffolds

Abstract

Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component.

1 . (canceled) 
     
     
         2 . A stent comprising a scaffold made from a blend of a matrix polymer and a random copolymer of a rubbery polymer component and a rigid polymer component,
 wherein the rubbery polymer component is selected from the group consisting of poly(4-hydroxy butyrate), polycaprolactone, polybutylene succinate, and polydioxanone,   wherein the rigid polymer component and the matrix polymer comprise poly(L-lactide) (PLLA),   wherein the rubbery polymer component is 1 to 15 wt % of the scaffold,   wherein the rubbery polymer component is 20 and 80 mol % of the copolymer,   wherein the scaffold comprises a plurality of rings with each of the rings having ring struts interconnected at hinge portions, such that the ring struts and the hinge portions form a unitary ring and the scaffold is configured for being plastically deformed when crimped to a balloon having a nominal inflation diameter, the scaffold having an expanded diameter when plastically deformed from a crimped state by the balloon inflated to the nominal inflation diameter, and the hinge portions are plastically deformed when the scaffold is crimped to the balloon and when the scaffold is expanded by the balloon.   
     
     
         3 . The stent of  claim 2 , wherein the number average molecular weight (Mn) of the copolymer is 30 to 500 kDa and is less than an Mn of the matrix polymer. 
     
     
         4 . The stent of  claim 2 , wherein the copolymer is poly(L-lactide-co-ε-caprolactone). 
     
     
         5 . The stent of  claim 2 , wherein the rubbery polymer component forms a dispersed phase with domains distributed throughout a matrix phase composed of the matrix polymer. 
     
     
         6 . The stent of  claim 2 , wherein the scaffold attains greater than 80% of its expanded diameter after being crushed to at least 50% of its expanded diameter.