US2016030624A1PendingUtilityA1

Methods and compositions for wound healing

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Assignee: IMBED BIOSCIENCES INCPriority: Jan 30, 2008Filed: Oct 14, 2015Published: Feb 4, 2016
Est. expiryJan 30, 2028(~1.5 yrs left)· nominal 20-yr term from priority
Inventors:Nicholas AbbottAnkit AgarwalChristopher MurphyJonathan F. Mcanulty
A61L 15/22A61L 15/42A61L 2300/104A61F 2013/0091A61L 15/46A61L 2400/12A61K 33/38A61L 2300/608A61L 2420/04A61P 17/02A61L 15/44B82Y 5/00A61L 15/225
48
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Claims

Abstract

The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.

Claims

exact text as granted — not AI-modified
1 .- 29 . (canceled) 
     
     
         30 . A method for synthesizing a device for treatment of a wound, comprising:
 a) assembling alternating layers of polyelectrolytes on a polymeric support to form a nanoscale polyelectrolyte multilayer on said support;   b) incubating said multilayer in bulk solution of a silver salt;   c) exposing said multilayer to a reducing agent to produce zerovalent silver ions.   
     
     
         31 . The method of  claim 30 , wherein at least one of said polyelectrolytes comprises a solution containing poly(allylamine hydrochloride). 
     
     
         32 . The method of  claim 30 , wherein at least one of said polyelectrolytes comprises a solution containing poly(acrylic acid). 
     
     
         33 . The method of  claim 30 , wherein said bulk solution of a silver salt comprises silver nitrate. 
     
     
         34 . The method of  claim 30 , wherein the concentration of Ag +  in said silver nitrate solution is about 5 mM. 
     
     
         35 . The method of  claim 32 , wherein the pH of said poly(acrylic acid) solution is about 2.5 to 7.5. 
     
     
         36 . A method for synthesizing a device for treatment of a wound, comprising:
 a) assembling alternating layers of polyelectrolytes to form a nanoscale polyelectrolyte multilayer;   b) incubating said multilayer in bulk solution of a silver salt;   c) exposing said multilayer to a reducing agent to produce zerovalent silver ions.   
     
     
         37 . The method of  claim 36 , wherein at least one of said polyelectrolytes comprises a solution containing poly(allylamine hydrochloride). 
     
     
         38 . The method of  claim 36 , wherein at least one of said polyelectrolytes comprises a solution containing poly(acrylic acid). 
     
     
         39 . The method of  claim 36 , wherein said bulk solution of a silver salt comprises silver nitrate. 
     
     
         40 . The method of  claim 36 , wherein the concentration of Ag +  in said silver nitrate solution is about 5 mM. 
     
     
         41 . The method of  claim 38 , wherein the pH of said poly(acrylic acid) solution is about 2.5 to 7.5.

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