Antimicrobial Amorphous Compositions

Abstract

The present invention comprises compositions and methods for providing antimicrobial compositions. The antimicrobial compositions comprise gel delivery vehicles comprising stabilized silver, wherein ionic silver is provided to a site for antimicrobial purposes. Methods of making and using such compositions are taught, including application of the silver-containing gel compositions to wounds, burns, abrasions, cuts, surgical incision, sites where skin or organ integrity has been breached, and other sites to supply an antimicrobial environment.

1 - 27 . (canceled) 
     
     
         28 . An antimicrobial composition comprising an amorphous delivery vehicle and a stabilized silver salt comprising silver ions and halide anions, wherein the stabilized silver salt is stabilized by a molar excess of halide anions to silver ions, wherein the antimicrobial composition is spreadable and resistant to discoloration due to light exposure. 
     
     
         29 . The composition of  claim 28 , wherein the halide anions comprise chloride anions. 
     
     
         30 . The composition of  claim 28 , wherein the stabilized silver salt comprises silver chloride. 
     
     
         31 . The composition of  claim 28 , wherein the stabilized silver salt is formed by combining silver nitrate and sodium chloride. 
     
     
         32 . The composition of  claim 28 , wherein the ratio of the molar excess of halide anions to silver ions ranges from 1.1:1 to 200:1. 
     
     
         33 . The composition of  claim 28 , further comprising glycerol. 
     
     
         34 . The composition of  claim 28 , further comprising a polymer matrix powder. 
     
     
         35 . The composition of  claim 34 , wherein the polymer matrix powder comprises polyacrylamide. 
     
     
         36 . The composition of  claim 28 , further comprising water. 
     
     
         37 . The composition of  claim 28 , further comprising an active agent. 
     
     
         38 . The composition of  claim 37 , wherein the active agent is an antimicrobial agent, an antifungal agent, an antibacterial agent, an antiviral agent, an anti-parasitic agent, a wound healing agent, or a combination thereof. 
     
     
         39 . The composition of  claim 28 , wherein the delivery vehicle comprises a polymeric composition comprising an aqueous composition of an alkylcellulose derivative, sodium carboxycellulose, carboxymethylcellulose, hydroxyethylcellulose, or hydroxypropyl cellulose. 
     
     
         40 . The composition of  claim 28 , wherein the delivery vehicle is present in an amount greater than 5 wt. % based on the total weight of the composition. 
     
     
         41 . The composition of  claim 28 , wherein the delivery vehicle comprises a water-in-oil or oil-in-water emulsion. 
     
     
         42 . The composition of  claim 28 , wherein the delivery vehicle comprises a hydrogel, a gel, a jelly, a lotion, an ointment, an emulsion, or a cream. 
     
     
         43 . The composition of  claim 28 , further comprising an electron acceptor. 
     
     
         44 . The composition of  claim 43 , wherein the electron acceptor comprises cupric chloride, ferric chloride, zinc chloride, gold, platinum, or cesium. 
     
     
         45 . The composition of  claim 28 , further comprising an oxidizing agent. 
     
     
         46 . The composition of  claim 45 , wherein the oxidizing agent comprises hydrogen peroxide or zinc peroxide. 
     
     
         47 . An antimicrobial composition comprising an amorphous delivery vehicle comprising a polymeric composition comprising an aqueous composition of an alkylcellulose derivative, sodium carboxycellulose, carboxymethylcellulose, hydroxyethylcellulose, or hydroxypropyl cellulose; a stabilized silver salt formed by combining silver nitrate with a molar excess of sodium chloride to provide a ratio of excess of halide anions to silver ions ranges from 1.1:1 to 200:1; glycerol; and an electron acceptor comprising cupric chloride, ferric chloride, zinc chloride, gold, platinum, or cesium, wherein the antimicrobial composition is spreadable and resistant to discoloration due to light exposure. 
     
     
         48 . The composition of  claim 47 , further comprising a polymer matrix powder comprising polyacrylamide.