US2016039858A1PendingUtilityA1
Substituted nucleosides, nucleotides and analogs thereof
Est. expiryDec 21, 2032(~6.4 yrs left)· nominal 20-yr term from priority
C07H 19/207A61P 31/14C07H 19/20C07H 19/16C07H 19/06C07H 19/213C07H 19/10C07H 19/173A61K 31/7076A61P 31/20
65
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Claims
Abstract
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.
Claims
exact text as granted — not AI-modified1 . (canceled)
2 . A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:
wherein:
B 1 is
R 1 is methyl or ethynyl;
R 2 is hydroxyl;
R 3 is hydroxyl;
R 4 is
R 5A is O − or OH;
R 5B is
where n is 0 or 1;
R 6A is unsubstituted C 1-6 alkyl;
R 9 , R 10 and R 11 are independently absent or hydrogen; and
Z 1 is O or S.
3 . The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein Z 1 is S.
4 . The compound of claim 3 , or a pharmaceutically acceptable salt thereof, wherein B 1 is
5 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 6A is methyl.
6 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 1 is methyl.
7 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 1 is ethynyl.
8 . The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein n is 1.
9 . The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein Z 1 is O.
10 . The compound of claim 9 , or a pharmaceutically acceptable salt thereof, wherein B 1 is
11 . The compound of claim 10 , or a pharmaceutically acceptable salt thereof, wherein R 1 is methyl.
12 . The compound of claim 10 , or a pharmaceutically acceptable salt thereof, wherein R 1 is ethynyl.
13 . The compound of claim 10 , or a pharmaceutically acceptable salt thereof, wherein n is 1.Join the waitlist — get patent alerts
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