Oral care compositions and methods of use

Abstract

Described herein are aqueous oral compositions comprising cationic steroidal compound and a quaternary ammonium compound; and methods for making and using the same.

1 . A method of treating a disease or condition of the oral cavity comprising administering a cationic steroidal compound according to the oral cavity of a subject in need thereof. 
     
     
         2 . The method of  claim 1 , wherein treating the disease or condition of the oral cavity includes reducing inflammation in the oral cavity. 
     
     
         3 . The method of  claim 1 , wherein treating the disease or condition of the oral cavity comprises reducing volatile sulfur compounds in the oral cavity. 
     
     
         4 . The method of  claim 1 , wherein treating the disease or condition of the oral cavity includes reducing gingivitis. 
     
     
         5 . The method of  claim 1 , wherein treating the disease or condition of the oral cavity includes reducing periodontitis. 
     
     
         6 . The method of  claim 1 , wherein treating the disease or condition of the oral cavity includes reducing caries. 
     
     
         7 . The method of  claim 1 , wherein the cationic steroidal compound is administered using an aqueous composition. 
     
     
         8 . The method of  claim 7 , wherein the aqueous composition has a free water content of at least about 40% by weight. 
     
     
         9 . The method of  claim 7 , wherein the aqueous composition has a free water content greater than about 50% by weight. 
     
     
         10 . The method of  claim 7 , wherein the aqueous composition has a free water content greater than about 60% by weight. 
     
     
         11 . The method of  claim 7 , wherein the aqueous composition is a mouthwash. 
     
     
         12 . The method of  claim 7 , wherein the aqueous composition further comprises a fluoride source. 
     
     
         13 . The method of  claim 12 , wherein the fluoride ion source is selected from the group consisting of stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof. 
     
     
         14 . The method of  claim 7 , wherein the cationic steroidal compound is present at a concentration of from about 0.01% to about 0.1% by weight of the aqueous composition. 
     
     
         15 . The method of  claim 1 , wherein the cationic steroidal compound is administered using a paste or gel composition. 
     
     
         16 . The method of  claim 1 , wherein the cationic steroidal compound is administered using at least one of a mouth rinse, mousse, foam, mouth spray, lozenge, tablet, dental implement, or pet care product. 
     
     
         17 . The method of  claim 1 , wherein the cationic steroidal compound is administered using a composition comprising the cationic steroidal compound and at least one of a buffering agent, humectant, cellulosic polymer, gum polymer, polyacrylate polymer or co-polymer, colorant, flavor agent, sweetener, breath freshening agent, tartar control agent, saliva stimulating agent, antiplaque agent, or desensitizing agent. 
     
     
         18 . The method of  claim 1 , wherein the cationic steroidal compound is a compound of Formula (I): 
       
         
           
           
               
               
           
         
         wherein R 1  is selected from —OH and NH—R 2 , wherein R 2  is C 2 -C 14  alkyl, C 2 -C 14  alkenyl or C 2 -C 14  alkynyl, and n is 3 or 4. 
       
     
     
         19 . The method of  claim 1 , wherein the compound of Formula (I), is selected from a compound of Formula (II): 
       
         
           
           
               
               
           
         
       
       or a compound of Formula (III): 
       
         
           
           
               
               
           
         
       
     
     
         20 . The method of  claim 1 , wherein cationic steroidal compound is a compound of Formula (II): 
       
         
           
           
               
               
           
         
       
     
     
         21 . A method of treating an inflammatory condition of the oral cavity comprising administering a composition comprising a cationic steroidal compound to the oral cavity of a subject in need thereof. 
     
     
         22 . The method of  claim 21 , wherein the cationic steroidal compound has a molecular weight of from about 500 to about 1000. 
     
     
         23 . A method of reducing volatile sulfur compounds comprising administering a composition comprising a cationic steroidal compound to the oral cavity of a subject in need thereof. 
     
     
         24 . The method of  claim 23 , wherein the cationic steroidal compound has a molecular weight of from about 500 to about 1000.