Kit containing photosensitizing dyes

Abstract

Generally regarded as safe (GRAS) dyes can be used as photosensitizing dyes in oral compositions to provide anti-bacterial and anti-inflammatory efficacy. Embodiments include oral care compositions including photosensitizing dyes, methods of making the compositions, methods of using the compositions, and kits containing the compositions and light emitting devices.

1 . A kit for treating and/or preventing conditions caused by microorganisms in a subject, the kit comprising an oral care composition comprising a photosensitizing dye, and a light emitting device capable of emitting light at a wavelength and for a period of time sufficient to activate the photosensitizing dye to treat and/or prevent the condition caused by microorganisms, wherein the photosensitizing dye is selected from the group consisting of Chlorophyllin sodium copper salt, Tartrazine (FD&C Yellow No. 5), Riboflavin 5′-monophosphate sodium salt, Allura Red AC (FD&C Red No. 40), New Coccine (CI 16255, Food Red 7), Chromotrope FB (CI 14720, Food Red 3), Indigo Carmine, Erioglaucine disodium salt (FD&C Blue No. 1), Fast Green FCF (FD&C Green No. 3), Lissamine Green B, Napthol Green or Acid Green, Cochineal, Carmoisine azorubine, Amaranth, Brillant Scarlet 4R, copper complexes of chlorophylls, Brillant black BN (PN), Chocolate Brown HT, Beta-carotene, Bixin, Lycopene, Betanin, Erythrosin B sodium salt, and mixtures thereof. 
     
     
         2 . The kit as claimed in  claim 1 , further comprising an applicator that is capable of applying the oral care composition to the oral cavity. 
     
     
         3 . The kit as claimed in  claim 1 , wherein the applicator also is the light emitting device, and is capable of irradiating the area to which the composition is administered with the applicator. 
     
     
         4 . The kit as claimed in  claim 1 , wherein the light emitting device is capable of emitting light at a wavelength from 380 nm to 780 nm, at a dosage of from 1 J/cm 2  to 450 J/cm 2 , with a power density of from about 1 to about 500 mW/cm 2 , and for a period of time of from 1 second to 120 minutes. 
     
     
         5 . The kit of  claim 1 , wherein the light has a wavelength of from 400 to 780 nm. 
     
     
         6 . The kit of  claim 1 , wherein the period of time is from 2 seconds to 15 minutes. 
     
     
         7 . The kit of  claim 1 , wherein light is emitted at a dosage of from 15 to 45 J/cm 2 . 
     
     
         8 . The kit of  claim 1 , wherein the light is emitted at a power density of from 175 to 250 mW/cm 2 . 
     
     
         9 . The kit of  claim 1 , wherein the photosensitizing dye is selected from the group consisting of Tartrazine, Curcumin, Allura Red, Fast Green FCF, and mixtures thereof. 
     
     
         10 . The kit of  claim 1 , wherein the photosensitizing dye is present in an amount ranging from about 0.001 to about 1% by weight. 
     
     
         11 . The kit of  claim 1 , wherein the oral care composition further comprises perfluorodecahydro naphthalene. 
     
     
         12 . The kit of  claim 1 , wherein the composition is in a form selected from the group consisting of: a liquid solution suitable for irrigating, rinsing or spraying; a dentifrice selected from a powder, toothpaste or dental gel; a periodontal gel; a liquid suitable for painting a dental surface; a chewing gum; a dissolvable, partially dissolvable or non-dissolvable film or strip; a bead; a wafer; a lozenge; a wipe or towelette; an implant; a mouthrinse; a foam; and a dental floss. 
     
     
         13 . The kit of  claim 1 , wherein the composition is a toothpaste, mouthrinse, or dental gel. 
     
     
         14 . The kit of  claim 1 , further comprising instructions for applying the oral care composition and irradiating the oral cavity with the light emitting device. 
     
     
         15 . The kit of  claim 1 , wherein the photosensitizing dye is Tartrazine. 
     
     
         16 . The kit of  claim 1 , wherein the photosensitizing dye is Allura Red or Fast Green FCF.