Small compounds targeting tacc3

Abstract

The present invention provides a small compound targeting at TACC3. The present invention further provides a drug, particularly, an anticancer agent, comprising the small compound targeting at TACC3. A compound represented by the general formula (I) or a pharmaceutically acceptable salt, solvate, or ester derivative thereof binds to TACC3 and inhibits cell growth. Thus, these compounds can be used as drugs, particularly, anticancer agents.

1 . A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of a cancer targeting at TACC3 and/or a TACC3-TOGp complex: 
       
         
           
           
               
               
           
         
         wherein R 1  represents 
       
       
         
           
           
               
               
           
         
         OAc, NEt 2 , NMe(CH 2 CH 2 OH), NH(CH 2 CH 2 NMe 2 ), NEt(CH 2 CH 2 NMe 2 ), N(CH 2 CH 2 OMe) 2 , N + O − (CH 2 CH 2 OMe) 2 , NMe(CH 2 ) 3 Me, or N(CH 2 CH 2 Me) 2 ; R 2  represents Ac or H; and R 3  represents H, Cl, F, or Br. 
       
     
     
         2 . The compound or the pharmaceutically acceptable salt thereof for use in the treatment of a cancer, targeting at TACC3 and/or a TACC3-TOGp complex according to  claim 1 , wherein
 the cancer targeting TACC3 is colon cancer, ovary cancer, uterine cancer, breast cancer, esophagus cancer, lymphoma, glioma, prostate cancer, kidney cancer, or melanoma.   
     
     
         3 . A method for producing an anticancer agent composition, comprising
 mixing a compound or a pharmaceutically acceptable salt thereof according to  claim 1  with a pharmaceutically acceptable excipient.   
     
     
         4 . The compound or the pharmaceutically acceptable salt thereof for use in the treatment of a cancer, targeting at TACC3 and/or a TACC3-TOGp complex according to  claim 1 , wherein the compound or the pharmaceutically acceptable salt thereof is selected from the group consisting of: