(-)-epigallocatechin gallate derivatives for inhibiting proteasome

Abstract

A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:

1 . A method of manufacturing a medicament for treating hematological cancers, the method comprising forming a medicament comprising a compound having the formula: 
       
         
           
           
               
               
           
         
       
       wherein
 R 5  is —H; and 
 wherein the formula satisfies one of the following conditions (1) to (4): 
 (1) each of R 11 , R 12 , R 13 , R 21 , R 22 , R 2 , R 3 , and R 4  is an acetate group; 
 (2) each of R 11 , R 12 , R 13 , R 21 , R 22 , and R 2  is an acetate group, and each of R 3  and R 4  is —H; 
 (3) each of R 11 , R 12 , R 13 , R 21 , R 22  is an acetate group, each of R 2  and R 4  is an acetate group, and R 3  is —H; 
 (4) each of R 11 , R 12 , R 13 , R 21 , R 22 , and R 3  is an acetate group, and each of R 2  and R 4  is —H. 
 
     
     
         2 . A method of manufacturing a medicament for treating hematological cancers, the method comprising forming a medicament comprising a compound having the formula: 
       
         
           
           
               
               
           
         
       
       wherein the formula satisfies one of conditions (1) to (3):
 (1) R 1  is —H, R 2  is —OH, and each of R 3  and R 4  is —H; 
 (2) R 1  is —H, each of R 2  and R 4  is —H, and R 3  is —OH; 
 (3) R 1  is —H, each of R 2  and R 4  is —OH, and R 3  is —H. 
 
     
     
         3 . The method of  claim 1 , wherein each of R 11 , R 12 , R 13 , R 21 , R 22 , R 2 , R 3 , R 4  is an acetate group. 
     
     
         4 . The method of  claim 1 , wherein each of R 11 , R 12 , R 13 , R 21 , and R 22  is an acetate group, R 2  is an acetate group, and each of R 3  and R 4  is —H. 
     
     
         5 . The method of  claim 1 , wherein each of R 11 , R 12 , R 13 , R 21 , R 22 , and R 3  is an acetate group, and each of R 2  and R 4  is —H. 
     
     
         6 . The method of  claim 1 , wherein each of R 11 , R 12 , R 13 , R 21 , and R 22  is an acetate group, each of R 2  and R 4  is an acetate group, and R 3  is —H. 
     
     
         7 . The method of  claim 2 , wherein the formula satisfies condition (1). 
     
     
         8 . The method of  claim 2 , wherein the formula satisfies condition (2). 
     
     
         9 . The method of  claim 2 , wherein the formula satisfies condition (3). 
     
     
         10 . A compound having the formula: 
       
         
           
           
               
               
           
         
       
       wherein
 R 5  is —H; and 
 wherein the formula satisfies one of the following conditions (1) to (3): 
 (1) each of R 11 , R 12 , R 13 , R 21 , R 22 , and R 2  is an acetate group, and each of R 3  and R 4  is —H; 
 (2) each of R 11 , R 12 , R 13 , R 21 , R 22  is an acetate group, each of R 2  and R 4  is an acetate group, and R 3  is —H; 
 (3) each of R 11 , R 12 , R 13 , R 21 , R 22 , and R 3  is an acetate group, and each of R 2  and R 4  is —H. 
 
     
     
         11 . The compound of  claim 10 , wherein each of R 11 , R 12 , R 13 , R 21 , and R 22  is an acetate group, R 2  is an acetate group, and each of R 3  and R 4  is —H. 
     
     
         12 . The compound of  claim 10 , wherein each of R 11 , R 12 , R 13 , R 21 , R 22 , and R 3  is an acetate group, and each of R 2  and R 4  is —H. 
     
     
         13 . The compound of  claim 10 , wherein each of R 11 , R 12 , R 13 , R 21 , and R 22  is an acetate group, each of R 2  and R 4  is an acetate group, and R 3  is —H.