Killing antibiotic-resistant bacteria with a formulation that is safe for oral administration

Abstract

The teachings provided herein generally relate to binding systems that kill antibiotic-resistant bacteria, wherein the binding systems are safe for oral administration. More particularly, the systems taught herein include methods of treating a subject having an antibiotic-resistant bacterial infection, comprising administering an effective amount of a binding system to a subject having an antibiotic-resistant bacterial infection. The binding system can be administered orally in a formulation having, for example, a tannin having a gallic acid ester and hydrogen peroxide in a pharmaceutically acceptable carrier.

We claim: 
     
         1 . A method of killing an antibiotic-resistant bacteria, comprising:
 contacting an effective amount of a binding system to a subject having an antibiotic-resistant bacteria, the binding system comprising a combination of:   a tannin having a gallic acid ester and a molecular weight ranging from about 500 Daltons to about 4000 Daltons; and,   hydrogen peroxide;   
       wherein,
 the hydrogen peroxide is combined with the tannin at a weight ratio that ranges from about 1:1000 to about 10:1 of the tannin to the hydrogen peroxide; and, 
 the combination is effective at killing the antibiotic-resistant bacteria. 
 
     
     
         2 . The method of  claim 1 , wherein the binding system further comprises an ellagitannin. 
     
     
         3 . The method of  claim 1 , wherein the binding system further comprises a gallotannin. 
     
     
         4 . The method of  claim 1 , wherein the binding system further comprises a punicalagin. 
     
     
         5 . The method of  claim 1 , wherein the binding system further comprises a catechin. 
     
     
         6 . The method of  claim 1 , wherein the antibiotic-resistant bacteria is a methicillin resistant  staphylococcus aureus  (MRSA). 
     
     
         7 . The method of  claim 1 , wherein the antibiotic-resistant bacteria is an antibiotic-resistant  Klebsiella pneumonia.    
     
     
         8 . The method of  claim 1 , wherein the antibiotic-resistant bacteria is an antibiotic-resistant bacteria selected from the group consisting of  Escherichia coli, Salmonella enterica  serotype  typhimurium, Staphylococcus aureus , a methicillin resistant  staphylococcus aureus  (MRSA),  Pseudomonas aeruginosa, Listeria monocytogenes, Pasteurella multocida, Proteus vulgaris, Klebsiella pneumonia, Bacillus cereus, Bordetella bronchiseptica.    
     
     
         9 . The method of  claim 1 , wherein the antibiotic-resistant bacteria is an antibiotic-resistant  Salmonella enterica  serotype  typhimurium.    
     
     
         10 . The method of  claim 1 , wherein the antibiotic-resistant bacteria is an antiobiotic-resistant  Pseudomonas aeruginosa.    
     
     
         11 . A formulation for killing antibiotic-resistant bacteria, comprising a combination of:
 a tannin having a gallic acid ester and a molecular weight ranging from about 500 Daltons to about 4000 Daltons;   hydrogen peroxide; and,   a pharmaceutically acceptable carrier;   wherein,   the binding system formulation is created by combining the hydrogen peroxide with the tannin at a weight ratio that ranges from about 1:1000 to about 10:1 of the tannin to the hydrogen peroxide.   
     
     
         12 . The formulation of  claim 11 , wherein the binding system further comprises an ellagitannin. 
     
     
         13 . The formulation of  claim 11 , wherein the binding system further comprises a gallotannin. 
     
     
         14 . The formulation of  claim 11 , wherein the binding system further comprises a punicalagin. 
     
     
         15 . The formulation of  claim 11 , wherein the binding system further comprises a catechin. 
     
     
         16 . A method of treating a subject having an antibiotic-resistant bacterial infection, comprising:
 administering an effective amount of a binding system to a subject having an antibiotic-resistant bacterial infection, the binding system comprising a combination of:
 a tannin having a gallic acid ester and a molecular weight ranging from about 500 Daltons to about 4000 Daltons; and, 
 hydrogen peroxide; 
   wherein,
 the hydrogen peroxide is combined with the ellagitannin at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and, 
 the administering is effective at killing the antibiotic-resistant bacteria. 
   
     
     
         17 . The method of  claim 16 , wherein the binding system further comprises an ellagitannin. 
     
     
         18 . The method of  claim 16 , wherein the binding system further comprises a gallotannin. 
     
     
         19 . The method of  claim 16 , wherein the binding system further comprises a punicalagin. 
     
     
         20 . The method of  claim 16 , wherein the binding system further comprises a catechin. 
     
     
         21 . The method of  claim 16 , wherein the antibiotic-resistant bacteria is a methicillin resistant  staphylococcus aureus  (MRSA). 
     
     
         22 . The method of  claim 16 , wherein the antibiotic-resistant bacteria is an antibiotic-resistant  Klebsiella pneumonia.    
     
     
         23 . The method of  claim 16 , wherein the antibiotic-resistant bacteria is an antibiotic-resistant bacteria selected from the group consisting of  Escherichia coli, Salmonella enterica  serotype  typhimurium, Staphylococcus aureus , a methicillin resistant  staphylococcus aureus  (MRSA),  Pseudomonas aeruginosa, Listeria monocytogenes, Pasteurella multocida, Proteus vulgaris, Klebsiella pneumonia, Bacillus cereus, Bordetella bronchiseptica.    
     
     
         24 . The method of  claim 16 , wherein the antibiotic-resistant bacteria is an antibiotic-resistant  Salmonella enterica  serotype  typhimurium.    
     
     
         25 . The method of  claim 16 , wherein the antibiotic-resistant bacteria is an antiobiotic-resistant  Pseudomonas aeruginosa.