Process for the Preparation of (-)-(4-Chloro-Phenyl)-(3-Trifluoromethyl-Phenoxy)-Acetic Acid 2-Acetylamino-Ethyl Ester

Abstract

The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid, a synthesis intermediate.

1 .- 57 . (canceled) 
     
     
         58 . A compound that is (−)-4-chlorophenyl-(3-trifluoromethyl-phenoxy)acetic acid 2-acetylamino-ethyl ester in crystalline solid form having an enantiomeric excess of 99.7% to 99.9% and a chemical purity of 99.1% to 99.6%. 
     
     
         59 . The compound of  claim 58  having an enantiomeric excess of greater than 99.9% and a chemical purity of 99.9%. 
     
     
         60 . The compound of  claim 59 , where the compound has been recrystallized. 
     
     
         61 . The compound of  claim 60 , where the compound has been recrystallized from a single solvent. 
     
     
         62 . The compound of  claim 61 , where the single solvent is diisopropyl ether. 
     
     
         63 . A compound that is (−)-(4-chlorophenyl)-(3-trifluoromethyl-phenoxy)acetic acid in crystalline solid form having an enantiomeric excess of 97.5% to 99.5% and a chemical purity of 97.5% to 99.5%.