US2016075762A1PendingUtilityA1

Albumin variants

64
Assignee: NOVOZYMES BIOPHARMA DK ASPriority: Oct 30, 2009Filed: Sep 24, 2015Published: Mar 17, 2016
Est. expiryOct 30, 2029(~3.3 yrs left)· nominal 20-yr term from priority
Inventors:Darrell SleepAndrew PlumridgeJason CameronInger SandlieJan Terje AndersenEsben Peter Friis
C07K 14/765A61P 43/00A61K 45/06C07K 2319/20C07K 2319/31C07K 14/54
64
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Claims

Abstract

The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.

Claims

exact text as granted — not AI-modified
1 . A variant of albumin comprising a substitution in a position corresponding to position 574 in the amino acid sequence of SEQ ID NO:2, wherein the substitution is selected from the group consisting of K574A,C,D,E,F,G,H,I, L,M,N,P,Q,R,S,T,V,W, and Y, and wherein the variant has at least 90% sequence identity to the amino acid sequence of SEQ ID NO:2. 
     
     
         2 . The variant of  claim 1 , wherein the variant has at least 98% sequence identity to the amino acid sequence of SEQ ID NO:2. 
     
     
         3 . The variant of  claim 1 , wherein the variant consists of the amino acid sequence of SEQ ID NO:2 with a substitution at position 574. 
     
     
         4 . The variant of  claim 1 , wherein the substitution is K574A. 
     
     
         5 . The variant of  claim 1 , wherein the substitution is K574C. 
     
     
         6 . The variant of  claim 1 , wherein the substitution is K574D. 
     
     
         7 . The variant of  claim 1 , wherein the substitution is K574E. 
     
     
         8 . The variant of  claim 1 , wherein the substitution is K574F. 
     
     
         9 . The variant of  claim 1 , wherein the substitution is K574G. 
     
     
         10 . The variant of  claim 1 , wherein the substitution is K574H. 
     
     
         11 . The variant of  claim 1 , wherein the substitution is K574I. 
     
     
         12 . The variant of  claim 1 , wherein the substitution is K574L. 
     
     
         13 . The variant of  claim 1 , wherein the substitution is K574M. 
     
     
         14 . The variant of  claim 1 , wherein the substitution is K574N. 
     
     
         15 . The variant of  claim 1 , wherein the substitution is K574P. 
     
     
         16 . The variant of  claim 1 , wherein the substitution is K574Q. 
     
     
         17 . The variant of  claim 1 , wherein the substitution is K574R. 
     
     
         18 . The variant of  claim 1 , wherein the substitution is K574S. 
     
     
         19 . The variant of  claim 1 , wherein the substitution is K574T. 
     
     
         20 . The variant of  claim 1 , wherein the substitution is K574V. 
     
     
         21 . The variant of  claim 1 , wherein the substitution is K574W. 
     
     
         22 . The variant of  claim 1 , wherein the substitution is K574Y.

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