Ectoparasiticidal formulations

Abstract

The invention provides an ectoparasiticidal formulation which comprises an ectoparasiticidal agent, preferably the pyrethroid tetramethrin, as the pesticidally-active ingredient, together with a crystallization inhibitor selected from the group consisting of alkyl-substituted pyrrolidones, and optionally, one or more organic solvents and/or co-solvents. Preferably, the crystallization inhibitor is N-octyl pyrrolidone, and the organic solvent, if present, preferably comprises diethylene glycol monoethyl ether. The ectoparasiticidal formulation surprisingly yields a significantly enhanced speed of kill. Methods for manufacturing the formulation, as well as methods for treating animals infested with ectoparasites, are also disclosed.

1 . A composition for the treatment of an ectoparasiticidal infestation on an animal, the composition comprising (a) the pyrethroid tetramethrin, (b) a crystallization inhibitor selected from the group consisting of N-methyl pyrrolidone, N-octyl pyrrolidone and N-dodecyl pyrrolidone, and (b) at least one organic solvent, wherein said composition excludes neonicotinoids, chlorantranilprole and cyantraniliprole. 
     
     
         2 . The composition of  claim 1 , wherein the crystallization inhibitor is N-octyl pyrrolidone. 
     
     
         3 . The composition of  claim 1 , wherein said at least one organic solvent comprises diethylene glycol monoethyl ether. 
     
     
         4 . The composition of  claim 1 , wherein the pyrethroid tetramethrin is present in an amount comprising from about 1% to about 20% by weight of the overall composition, and wherein said crystallization inhibitor is present in an amount comprising from about 1% to about 90% by weight of the overall composition. 
     
     
         5 . The composition of  claim 4 , wherein the pyrethroid tetramethrin is present in an amount comprising from about 7% to about 11% by weight of the overall composition, and wherein said crystallization inhibitor is present in an amount comprising from about 10% to about 20% by weight of the overall composition. 
     
     
         6 . The composition of  claim 1 , wherein said at least one organic solvent is selected from the group consisting of acetone, benzyl alcohol, butyl diglycol, dipropylene glycol n-butyl ether, ethanol, isopropanol, methanol, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, dipropylene glycol monoethyl ether, propylene glycol, diethylene glycol monoethyl ether, ethylene glycol, cyclic carbonates, lactones, and mixtures of at least two of said solvents. 
     
     
         7 . The composition of  claim 5 , further comprising at least one organic co-solvent selected from the group consisting of ethanol, isopropanol, and methanol, and wherein said at least one organic solvent is present in a proportion with said at least one organic co-solvent ranging from about 1:99 to about 99:1. 
     
     
         8 . The composition of  claim 7 , wherein said at least one organic solvent comprises diethylene glycol monoethyl ether and said at least one organic co-solvent comprises ethanol. 
     
     
         9 . The composition of  claim 1 , further including at least one insect growth regulator. 
     
     
         10 . A composition for the treatment of an ectoparasiticidal infestation on an animal, the composition comprising (a) the pyrethroid tetramethrin, (b) N-octyl pyrrolidone, and (c) at least one organic solvent. 
     
     
         11 . The composition of  claim 10 , wherein said at least one organic solvent comprises diethylene glycol monoethyl ether. 
     
     
         12 . The composition of  claim 10 , wherein the pyrethroid tetramethrin is present in an amount comprising from about 7.0% to about 11.0% by weight of the overall composition, and wherein N-octyl pyrrolidone is present in an amount comprising from about 10% to about 20% by weight of the overall composition. 
     
     
         13 . The composition of  claim 10 , wherein said at least one organic solvent is selected from the group consisting of acetone, benzyl alcohol, butyl diglycol, dipropylene glycol n-butyl ether, ethanol, isopropanol, methanol, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, dipropylene glycol monoethyl ether, propylene glycol, diethylene glycol monoethyl ether, ethylene glycol, cyclic carbonates, lactones, and mixtures of at least two of said solvents. 
     
     
         14 . The composition of  claim 10 , wherein (a) the pyrethroid tetramethrin is present in an amount comprising from about 1% to about 20% by weight of the overall composition, and (b) N-octyl pyrrolidone is present in an amount comprising from about 1% to about 10% by weight of the overall composition. 
     
     
         15 . The composition of  claim 10 , further including at least one insect growth regulator. 
     
     
         16 . A composition for the treatment of an ectoparasiticidal infestation on animal, the composition comprising (a) tetramethrin, (b) a crystallization inhibitor selected from the group consisting of N-methyl pyrrolidone, N-octyl pyrrolidone and N-dodecyl pyrrolidone, and (c) at least one organic solvent. 
     
     
         17 . The composition of  claim 16  wherein said at least one organic solvent is diethylene glycol monotheyl ether. 
     
     
         18 . The composition of  claim 16 , wherein said at least one organic solvent is selected from the group consisting of acetone, benzyl alcohol, butyl diglycol, dipropylene glycol n-butyl ether, ethanol, isopropanol, methanol, ethylene glycol monoethyl ether, ethylene glycol monomethyl ether, dipropylene glycol rnonoethyl ether, propylene glycol, diethylene glycol monoethyl ether, ethylene glycol, cyclic carbonates, lactones, and mixtures of at least two of said solvents. 
     
     
         19 . The composition of  claim 16 , further including at least one insect growth regulator. 
     
     
         20 . The composition of  claim 18 , further including at least one organic co-solvent selected from the group consisting of ethanol, isopropanol and methanol.