Benzothiazole derivative and anti-tumor use thereof

Abstract

The present invention relates to a benzothiazole derivative of formula 1 or a pharmaceutically acceptable salt thereof and a process for preparation thereof. The present invention also relates to a pharmaceutical composition comprising the compounds and the use of the compounds in the preparation of an anti-tumor medicament.

1 - 7 . (canceled) 
     
     
         8 . A method for treating a cancer associated with abnormal activity of TRPC6 comprising administering an effective amount of a compound which is 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt or prodrug thereof to a subject in need thereof. 
     
     
         9 . The method according to  claim 8 , wherein the cancer is selected from breast cancer, lung cancer, prostate cancer and oral epithelium carcinoma.