Method for left atrial appendage occlusion

Abstract

Disclosed is an occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device includes an occlusion member and may also include a stabilizing member. The stabilizing member inhibits compression of the left atrial appendage, facilitating tissue in-growth onto the occlusion member. Methods are also disclosed.

1 . (canceled) 
     
     
         2 . A containment device for positioning at a left atrial appendage comprising:
 a proximal end, a proximal portion, a distal end, a distal portion, an intermediate portion between the proximal end and the distal end, and a longitudinal axis extending therethrough;   a proximal hub;   a one-piece frame having a proximal end, a proximal portion, a distal portion, an intermediate portion between the proximal portion and the distal portion, and a distal end and,   wherein the proximal end of the one-piece frame is fixedly attached to the proximal hub; and   a membrane or mesh covering the proximal portion and at least a portion of the intermediate portion,   wherein the proximal hub is located near a center of the containment device and includes a detachment mechanism configured and adapted to releasably mate with a delivery catheter or a push rod associated with a delivery catheter, and   wherein the one-piece frame includes a plurality of struts defining a plurality of fenestrations at least some of which extend from the proximal hub to the intermediate portion.   
     
     
         3 . The containment device of  claim 2 , wherein a proximal portion of the one-piece frame initially extends distally from the proximal hub while curving concave outward and then curving convex outward to form a proximal end of the intermediate portion when the containment device is in a deployed configuration. 
     
     
         4 . The containment device of  claim 2 , wherein distalmost portions of the one-piece frame collectively define a plane which lies proximal of the proximal hub when the containment device is in a deployed configuration. 
     
     
         5 . The containment device of  claim 2 , wherein the membrane or mesh covering the proximal portion and at least a portion of the intermediate portion is an endothelialization membrane. 
     
     
         6 . The containment device of  claim 2 , wherein the membrane or mesh is a composite membrane. 
     
     
         7 . The containment device of  claim 2 , wherein the membrane or mesh provides a barrier secured to a radially inward facing surface of the one-piece frame. 
     
     
         8 . The containment device of  claim 2 , wherein the membrane or mesh provides a barrier secured to a radially outward facing surface of the one-piece frame. 
     
     
         9 . The containment device of  claim 2 , wherein the membrane or mesh provides a barrier secured to both a radially inward facing surface of the one-piece frame and a radially outward facing surface of the one-piece frame. 
     
     
         10 . The containment device of  claim 2 , wherein the intermediate portion of the containment device is cylindrical. 
     
     
         11 . The containment device of  claim 2 , wherein the intermediate portion of the containment device is includes a distal taper. 
     
     
         12 . The containment device of  claim 2 , wherein the intermediate portion of the one-piece frame includes a plurality of tissue-engaging barbs or other anchors. 
     
     
         13 . The containment device of  claim 12 , wherein each strut of the plurality of struts of the intermediate portion of the one-piece frame includes at least one tissue-engaging barb or other anchor. 
     
     
         14 . The containment device of  claim 12 , wherein each at least one tissue-engaging barb or other anchor lies distal of the membrane or mesh. 
     
     
         15 . The containment device of  claim 2 , wherein the distal end defines a diameter which is smaller than a diameter of the intermediate portion. 
     
     
         16 . The containment device of  claim 2 , wherein the distal portion is convex outward. 
     
     
         17 . The containment device of  claim 2 , wherein the one-piece frame is configured and adapted to move between a state in which the plurality of struts are radially contracted and a state in which the plurality of struts are radially expanded. 
     
     
         18 . The containment device of  claim 17 , wherein moving the delivery catheter allows the one-piece frame to move between a state in which the plurality of struts are radially contracted and a state in which the plurality of struts are radially expanded. 
     
     
         19 . The containment device of  claim 2 , wherein release of the detachment mechanism included in the proximal hub from the delivery catheter or pushrod associated with the delivery catheter allows the delivery catheter or pushrod associated with the delivery catheter to be withdrawn. 
     
     
         20 . The containment device of  claim 2 , wherein the proximal hub includes a lumen having a self sealing valve or gasket which prevents passage of fluid or embolic material through the lumen of the proximal hub. 
     
     
         21 . The containment device of  claim 2 , wherein the distal portion includes a distal hub to which the distal end of the one-piece frame is attached.