Method of treating nasopharyngeal carcinoma using perillyl alcohol derivative

Abstract

A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH) carbamate which is a perillyl alcohol conjugated with temozolomide (TMZ).

What is claimed is: 
     
         1 . A method for treating nasopharyngeal carcinoma in a mammal, comprising the step of delivering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, wherein the perillyl alcohol carbamate comprises perillyl alcohol conjugated with temozolomide (TMZ). 
     
     
         2 . The method of  claim 1 , further comprising the step of treating the mammal with radiation. 
     
     
         3 . The method of  claim 1 , further comprising the step of delivering to the mammal one or more chemotherapeutic agents. 
     
     
         4 . The method of  claim 3  wherein the chemotherapeutic agent is selected from the group consisting of Rituximab, Beuacizumab, Trastuzumab, Imatinib, Lenalidomide, Pemetrexed, Bortezomib, Cetuximab, Leuprorelin, Abiraterone, 5-Fluorouracil, Doxorubicin, Epirubicin, Gemeitabine, Methotrexate, all trans Retinoic Acid, Azacitidine, Azathioprine, Bleomycin, Carboplatin, Capecitabine, Cisplatin, Chlorambucil, Cyclophosphoramide, Cytarabine, Daunorubicin, Docetaxel, Doxifluridine, Epothilone, Etoposide, Hydroxyurea, Idarubicin, Irinotecan, Mechlorethamine, Mercaptopurine, Methotrexate, Mitoxantrone, Oxaliplatin, Paclitaxel, Teniposide, Tioguanine, Topotecan, Valrubicin, Vincristine, Vinblastine, Vindesine and Vinorelbine 
     
     
         5 . The method of  claim 1 , wherein the perillyl alcohol carbamate is administered by inhalation, intranasally, orally, intravenously, subcutaneously or intramuscularly. 
     
     
         6 . The method of  claim 5 , wherein the perillyl alcohol carbamate is administered intranasally using an atomizer. 
     
     
         7 . The method of  claim 1 , wherein the perillyl alcohol carbamate is 3-methyl 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)-carbamic acid-4-isopropenyl cyclohex-1-enylmethyl ester. 
     
     
         8 . The method of  claim 1 , wherein delivering the perillyl alcohol carbamate to the mammal comprises delivering the perillyl alcohol carbamate by a nasal delivery device. 
     
     
         9 . The method of  claim 8 , wherein the nasal delivery device is selected from the group consisting of an intranasal inhaler, an intranasal spray device, an atomizer, a nebulizer, a metered dose inhaler (MDI), a pressurized dose inhaler, an insufflator, a unit dose container, a pump, a dropper, a nasal spray bottle, a squeeze bottle and a bi-directional device.