Method for inhibiting platelet aggregation

Abstract

A method for inhibiting platelet aggregation in a patient in need thereof, comprising 1) administering to the patient a bolus injection of an active drug, in an amount of between about 25 μg/kg, and 2) administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of the active drug, in an amount of about 0.15 μg/kg/min, wherein the active drug is tirofiban or a salt thereof.

1 . A method for reducing the risk of thrombosis, thromboembolism or reocclusion in a patient after surgery on peripheral arteries, comprising administering to the patient a bolus injection of about 25 μg/kg of tirofiban or salt thereof to inhibit platelet aggregation. 
     
     
         2 . The method of claim wherein the patient underwent peripheral arterial intervention. 
     
     
         3 . The method of  claim 1  wherein the platelet aggregation occurs in peripheral arteries. 
     
     
         4 . The method of  claim 1  wherein the bolus injection is at least 20 μg/kg of tirofiban or salt thereof. 
     
     
         5 . The method of  claim 1 , wherein the salt is tirofiban hydrochloride. 
     
     
         6 . The method of  claim 1 , further comprising administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of tirofiban or salt thereof to inhibit platelet aggregation, in an amount of about 0.15 μg/kg/min. 
     
     
         7 . The method of  claim 6  wherein the intravenous infusion is about 12 hours. 
     
     
         8 . A method of preventing platelet thrombosis, thromboembolism or reocclusion after surgery on peripheral arteries in a patient comprising administering to the patient a bolus injection of tirofiban or salt thereof, in amounts sufficient to inhibit platelet aggregation. 
     
     
         9 . The method of  claim 8  wherein the patient underwent peripheral arterial intervention. 
     
     
         10 . The method of  claim 8  wherein the platelet aggregation occurs in peripheral arteries. 
     
     
         11 . The method of  claim 8  wherein the bolus injection is at least 20 μg/kg of tirofiban or salt thereof. 
     
     
         12 . The method of  claim 8 , wherein the salt is tirofiban hydrochloride. 
     
     
         13 . The method of  claim 8 , further comprising administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of tirofiban or salt thereof to inhibit platelet aggregation, in an amount of about 0.15 μg/kg/min. 
     
     
         14 . The method of  claim 8  wherein the intravenous infusion is about 12 hours. 
     
     
         15 . A method of preventing myocardial infarction in a patient after surgery on peripheral arteries in a patient comprising administering to the patient a bolus injection of tirofiban or salt thereof. 
     
     
         16 . The method of  claim 15  wherein the patient underwent peripheral arterial intervention. 
     
     
         17 . The method of  claim 15  wherein the bolus injection is at least 20 μg/kg of tirofiban or salt thereof. 
     
     
         18 . The method of  claim 15 , wherein the salt is tirofiban hydrochloride. 
     
     
         19 . The method of  claim 15 , further comprising administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of tirofiban or salt thereof to inhibit platelet aggregation, in an amount of about 0.15 μg/kg/min. 
     
     
         20 . The method of  claim 15  wherein the intravenous infusion is about 12 hours.