Devices and methods for thermal ablation of biological tissue using geometric ablation patterns

Abstract

A tissue ablation system including numerous components and methods is described herein for encircling target tissue and generating tissue ablation volumes in various biological tissues. The biological tissue includes tissue of a variety of organs of the human body including the liver, spleen, kidney, lung, breast and other organs, but is not so limited. The tissue ablation device comprises an energy source and at least one trocar coupled to the energy source, the trocar having a body, a proximal end, and a distal end. The trocar carries an electrode array that comprises a plurality of electrodes, each electrode of the plurality of electrodes is configured to extend from the trocar when moved from a retracted state to a deployed state, and to have at least one radius of curvature in the deployed state so that the electrode array forms a series of shaped electrodes in the deployed state.

1 . A tissue ablation device, comprising:
 a trocar including a distal end and a lumen extending along a longitudinal axis of the trocar, wherein the trocar includes a plurality of orifices positioned along the longitudinal axis; and   an electrode array comprising a plurality of electrodes, wherein the plurality of electrodes is positioned in the lumen in a retracted state, wherein the plurality of electrodes is deployed to a deployed state through a set of orifices of the plurality of orifices, wherein each electrode of the plurality of electrodes has at least one radius of curvature in the deployed state so that the electrode array forms a series of shaped electrodes in the deployed state.   
     
     
         2 . The device of  claim 1 , wherein the at least one radius of curvature is proportional to a size of an ablation volume generated with the electrode array in the deployed state. 
     
     
         3 . The device of  claim 1 , wherein the at least one radius of curvature is determinative of a shape of an ablation volume generated with the electrode array in the deployed state. 
     
     
         4 . The device of  claim 1 , wherein each electrode of the plurality of electrodes in the deployed state has an effective surface area proportional to the at least one radius of curvature. 
     
     
         5 . The device of  claim 1 , wherein the electrode array in the deployed state forms a planar series of shaped electrodes. 
     
     
         6 . The device of  claim 1 , wherein the electrode array in the deployed state forms a linear series of shaped electrodes aligned along the longitudinal axis. 
     
     
         7 . The device of  claim 1 , wherein a shape of the shaped electrodes is an ellipse. 
     
     
         8 . The device of  claim 1 , wherein a shape of the shaped electrodes is a circle. 
     
     
         9 . The device of  claim 1 , wherein a shape of the shaped electrodes is a semicircle. 
     
     
         10 . The device of  claim 1 , wherein the distal end of the trocar includes a sharp region for piercing tissue. 
     
     
         11 . The device of  claim 1 , wherein a distal tip of each electrode of the plurality of electrodes includes a sharp region for penetrating tissue. 
     
     
         12 . The device of  claim 1 , wherein distal tips of each of the plurality of electrodes, when transitioning from the retracted state to the deployed state, transition through approximately all points in a plane at a distance from a fixed center reference point, wherein the distance is the at least one radius of curvature. 
     
     
         13 . The device of  claim 1 , wherein distal tips of each of the plurality of electrodes, when transitioning from the retracted state to the deployed state, transition through a majority of points in a plane at a distance from a fixed center reference point, wherein the distance is the at least one radius of curvature. 
     
     
         14 . The device of  claim 1 , wherein distal tips of each of the plurality of electrodes, when transitioning from the retracted state to the deployed state, transition through approximately all points in a plane such that a sum of distances to a first fixed point and a second fixed point of the points is a constant. 
     
     
         15 . The device of  claim 1 , wherein distal tips of each of the plurality of electrodes, when transitioning from the retracted state to the deployed state, transition through a majority of points in a plane such that a sum of distances to a first fixed point and a second fixed point of the points is a constant. 
     
     
         16 . The device of  claim 1 , wherein the plurality of electrodes is deployed to a partially deployed state. 
     
     
         17 . The device of  claim 16 , wherein distal tips of each of the plurality of electrodes, when transitioning from the retracted state to the partially deployed state, transition through a portion of points in a plane at a distance from a fixed center reference point, wherein the distance is the at least one radius of curvature. 
     
     
         18 . The device of  claim 16 , wherein distal tips of each of the plurality of electrodes, when transitioning from the retracted state to the partially deployed state, transition through a portion of points in a plane such that a sum of distances to a first fixed point and a second fixed point of the portion of points is a constant. 
     
     
         19 . The device of  claim 1 , wherein the plurality of electrodes includes two electrodes. 
     
     
         20 . The device of  claim 19 , wherein a first center of a first shape formed by a first electrode is offset from a second center of a second shape formed by a second electrode. 
     
     
         21 . The device of  claim 20 , wherein the first shape is a first ellipse having a first radius of curvature and the second shape is a second ellipse having a second radius of curvature. 
     
     
         22 . The device of  claim 21 , wherein the first radius of curvature is different than the second radius of curvature. 
     
     
         23 . The device of  claim 21 , wherein the first radius of curvature is approximately equivalent to the second radius of curvature. 
     
     
         24 . The device of  claim 1 , wherein the plurality of electrodes includes three electrodes. 
     
     
         25 . The device of  claim 24 , wherein a first center of a first shape formed by a first electrode is offset from one or more of a second center of a second shape formed by a second electrode and a third center of a third shape formed by a third electrode. 
     
     
         26 . The device of  claim 25 , wherein the first shape is a first ellipse having a first radius of curvature, the second shape is a second ellipse having a second radius of curvature, and the third shape is a third ellipse having a third radius of curvature. 
     
     
         27 . The device of  claim 26 , wherein the first radius of curvature is different than one or more of the second radius of curvature and the third radius of curvature. 
     
     
         28 . The device of  claim 26 , wherein the first radius of curvature is approximately equivalent to one or more of the second radius of curvature and the third radius of curvature. 
     
     
         29 . The device of  claim 1 , wherein the plurality of electrodes includes four electrodes. 
     
     
         30 . The device of  claim 29 , wherein a first center of a first shape formed by a first electrode is offset from one or more of a second center of a second shape formed by a second electrode, a third center of a third shape formed by a third electrode, and a fourth center of a fourth shape formed by a fourth electrode. 
     
     
         31 . The device of  claim 30 , wherein the first shape is a first ellipse having a first radius of curvature, the second shape is a second ellipse having a second radius of curvature, the third shape is a third ellipse having a third radius of curvature, and the fourth shape is a fourth ellipse having a fourth radius of curvature. 
     
     
         32 . The device of  claim 31 , wherein the first radius of curvature is different than one or more of the second radius of curvature, the third radius of curvature, and the fourth radius of curvature. 
     
     
         33 . The device of  claim 31 , wherein the first radius of curvature is approximately equivalent to one or more of the second radius of curvature, the third radius of curvature, and the fourth radius of curvature. 
     
     
         34 . The device of  claim 1 , wherein each electrode of the plurality of electrodes has a first polarity. 
     
     
         35 . The device of  claim 1 , wherein a first set of electrodes of the plurality of electrodes has a first polarity and a second set of electrodes of the plurality of electrodes has a second polarity. 
     
     
         36 . The device of  claim 1 , wherein the plurality of electrodes is deployed laterally through the plurality of orifices to the deployed state. 
     
     
         37 . The device of  claim 1 , wherein the plurality of electrodes comprise flat wire electrodes. 
     
     
         38 . The device of  claim 1 , wherein at least one electrode of the plurality of electrodes comprises one or more of a flat wire electrode, a round wire electrode, a flat tube electrode, and a round tube electrode. 
     
     
         39 . The device of  claim 1 , wherein each orifice of the plurality of lateral orifices is longitudinally aligned with each other orifice along the longitudinal axis. 
     
     
         40 . The device of  claim 1 , wherein an electrode of the plurality of electrodes includes an electrode lumen. 
     
     
         41 . The device of  claim 1 , comprising a handle assembly coupled to the trocar and the electrode array. 
     
     
         42 . The device of  claim 1 , wherein the electrode array, when positioned in proximity to target tissue, defines an outer surface of an ablation volume. 
     
     
         43 . The device of  claim 1 , comprising an electromagnetic energy source and at least one cable, the at least one cable coupling the electrode array to the electromagnetic energy source. 
     
     
         44 . The device of  claim 43 , wherein the plurality of electrodes comprises a number of electrodes appropriate to create an ablation volume in target tissue without impeding out the electrode array when electromagnetic energy is delivered to the electrode array from the electromagnetic energy source. 
     
     
         45 . The device of  claim 44 , wherein the electrode array, when positioned in proximity to the target tissue, defines an outer surface of the ablation volume and at least partially encircles the ablation volume. 
     
     
         46 . The device of  claim 44 , wherein, when electromagnetic energy is delivered to the electrode array, the electrode array ablates the target tissue starting from the outer surface and progressing toward an inner portion of the target tissue. 
     
     
         47 . The device of  claim 1 , comprising at least one additional lumen extending along the longitudinal axis. 
     
     
         48 . A tissue ablation device, comprising:
 a trocar including a distal end, a lumen extending along a longitudinal axis of the trocar, and a plurality of orifices positioned along the longitudinal axis; and   an electrode array comprising a plurality of electrodes, wherein the plurality of electrodes is positioned in the lumen in a retracted state, wherein the plurality of electrodes is deployed to a deployed state through a set of the plurality of orifices, wherein each electrode of the plurality of electrodes has at least one radius of curvature in the deployed state so that the electrode array forms a series of shaped electrodes in the deployed state.   
     
     
         49 . A tissue ablation device, comprising:
 a trocar including a distal end and a lumen extending along a longitudinal axis of the trocar, wherein the distal end includes a sharp region for piercing tissue, wherein the trocar includes a plurality of orifices positioned along the longitudinal axis;   an electrode array comprising a plurality of electrodes, wherein the plurality of electrodes have a retracted state and a deployed state, wherein each electrode of the plurality of electrodes is contained in the lumen in the retracted state, wherein one or more electrode is deployed through an orifice of the plurality of orifices, wherein each electrode has a radius of curvature in the deployed state, wherein the electrode array forms a planar series of elliptical electrodes in the deployed state.   
     
     
         50 . A tissue ablation device, comprising:
 a trocar including a distal end and a lumen extending along a longitudinal axis of the trocar, wherein the trocar includes a plurality of orifices aligned along the longitudinal axis;   an electrode array comprising a plurality of electrodes, wherein the plurality of electrodes are deployed from the lumen via the plurality of orifices, wherein each electrode of the plurality of electrodes has at least one radius of curvature in a deployed state, wherein the electrode array in the deployed state forms a series of elliptical electrodes aligned along the longitudinal axis.   
     
     
         51 . A tissue ablation system, comprising:
 an ablation device comprising a trocar and an electrode array, wherein the trocar includes a distal end and a lumen extending along a longitudinal axis of the trocar, wherein the trocar includes a plurality of orifices positioned along the longitudinal axis, wherein the electrode array comprises a plurality of electrodes, wherein the plurality of electrodes is positioned in the lumen in a retracted state, wherein the plurality of electrodes is deployed to a deployed state through a set of the plurality of orifices, wherein each electrode of the plurality of electrodes has at least one radius of curvature in the deployed state so that the electrode array forms a series of shaped electrodes in the deployed state;   an electromagnetic energy source; and   at least one cable coupling the ablation device to the electromagnetic energy source.