Bone graft materials and methods

Abstract

Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size.

What is claimed is: 
     
         1 . A bone graft composition comprising:
 about 15% to about 20% by weight collagen;   about 55% to about 70% by weight bioactive glass, the bioactive glass including particles within a range of about 53 μm to about 425 μm in size, at least 85% of the bioactive glass particles being within a range of 212 μm to 425 μm in size; and   about 15% to about 30% by weight calcium phosphate.   
     
     
         2 . The bone graft composition of  claim 1 , wherein the bioactive glass particles and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. 
     
     
         3 . The bone graft composition of  claim 1 , wherein the collagen is type I collagen. 
     
     
         4 . The bone graft composition of  claim 1 , wherein the bioactive glass includes particles having a smooth surface. 
     
     
         5 . The bone graft composition of  claim 1 , wherein the calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite. 
     
     
         6 . The bone graft composition of  claim 5 , further comprising about 15% by weight type I collagen, about 55% to about 65% by weight bioactive glass, and about 20% to about 30% by weight calcium phosphate. 
     
     
         7 . The bone graft composition of  claim 6 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:55%:30%, respectively. 
     
     
         8 . The bone graft composition of  claim 6 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:60%:25%, respectively. 
     
     
         9 . The bone graft composition of  claim 6 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:65%:20%, respectively. 
     
     
         10 . The bone graft composition of  claim 1 , wherein the bioactive glass is 45S5 glass. 
     
     
         11 . A bone graft composition, comprising:
 a collagen carrier; and   a bioactive glass dispersed throughout the collagen carrier, the bioactive glass including particles having a size within a range of about 53 μm to about 425 μm, at least 85% of the bioactive glass particles having a size within a range of 212 μm to 425 μm;   wherein the collagen carrier is about 20% to about 60% by weight of the bone graft composition and the bioactive glass is about 40% to about 80% by weight of the bone graft composition.   
     
     
         12 . The bone graft composition of  claim 11 , wherein the collagen carrier is porous. 
     
     
         13 . The bone graft composition of  claim 11 , wherein the bioactive glass has a smooth surface. 
     
     
         14 . The bone graft composition of  claim 11 , wherein the bioactive glass is about 80% by weight of the bone graft composition. 
     
     
         15 . The bone graft composition of  claim 11 , wherein the bioactive glass is about 60% by weight of the bone graft composition. 
     
     
         16 . The bone graft composition of  claim 11 , wherein the bioactive glass is 45S5 glass. 
     
     
         17 . The bone graft composition of  claim 11 , wherein the collagen carrier includes type I collagen. 
     
     
         18 . The bone graft composition of  claim 11 , wherein the collagen carrier and the bioactive glass collectively comprise 100% by weight of the bone graft composition. 
     
     
         19 . A bone graft composition, comprising:
 a collagen carrier comprising about 10% to about 20% by weight of the bone graft composition;   a plurality of bioactive glass particles within the range of about 53 μm to about 425 μm in size and dispersed throughout the collagen carrier, at least 85% of the plurality of bioactive glass particles being within the range of 212 μm to 425 μm in size, the plurality of bioactive glass particles comprising about 25% to about 80% by weight of the bone graft composition, the plurality of bioactive glass particles each having a smooth surface.   
     
     
         20 . The bone graft composition of  claim 19 , wherein the collagen includes type I collagen.