Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof

Abstract

This invention relates to veterinary compositions for treating and/or preventing fleas or ticks infection or infestation in an animal comprising an isoxazoline active agent of Formula (II): or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

1 - 15 . (canceled) 
     
     
         16 . A method for treating and/or preventing a flea or tick infestation in an animal comprising administering to the animal an effective amount of a soft chewable veterinary composition comprising:
 a) an isoxazoline active agent of Formula (II):   
       
         
           
           
               
               
           
         
         pharmaceutically acceptable salt thereof; and 
         b) a pharmaceutically acceptable carrier, 
         wherein the carrier comprises a binder and a humectant, wherein the binder is PEG 3350 and the humectant is glycerol. 
       
     
     
         17 . The method of  claim 16 , wherein the humectant further comprises soy bean oil. 
     
     
         18 . The method of  claim 16 , wherein the carrier further comprises a lubricant which is magnesium stearate. 
     
     
         19 . The method of  claim 16 , wherein the carrier further comprises a surfactant which is sodium lauryl sulfate. 
     
     
         20 . The method of  claim 16 , wherein the carrier further comprises a filler which is corn starch or pre-gelatinized corn starch or a combination thereof. 
     
     
         21 . The method of  claim 16 , wherein the carrier further comprises a flavoring agent which is liver extract, pork, or artificial pork. 
     
     
         22 . The method of  claim 16 , wherein the composition comprises the compound of formula (II) at a concentration of about 1% to about 20% by weight. 
     
     
         23 . The method of  claim 21 , wherein the flavoring agent is present in a concentration of about 10% to about 30% (w/w). 
     
     
         24 . The method of  claim 20 , wherein the filler is present in a concentration of about 10% to about 40% (w/w). 
     
     
         25 . The method of  claim 19 , wherein the surfactant is present in a concentration of about 1 to about 5% (w/w). 
     
     
         26 . The method of  claim 18 , wherein the lubricant is present in a concentration of about 0.01 to about 20% (w/w). 
     
     
         27 . The method of  claim 16 , wherein the humectant is present in a concentration of about 1% to about 10% (w/w). 
     
     
         28 . The method of  claim 16 , wherein the binder is present at a concentration of about 1% to about 20% (w/w). 
     
     
         29 . The method of  claim 16 , wherein the pharmaceutically acceptable salt is a dicarboxylic acid or an aromatic salt. 
     
     
         30 . A method for treating and/or preventing a flea or tick infestation in an animal comprising administering to the animal an effective amount of a soft chewable veterinary composition comprising:
 a) an isoxazoline active agent of Formula (II):   
       
         
           
           
               
               
           
         
         pharmaceutically acceptable salt thereof; and 
         b) a pharmaceutically acceptable carrier, 
         wherein the carrier comprises:
 i) a filler selected from corn starch or pre-gelatinized corn starch or a combination thereof; 
 ii) a flavoring agent which is natural or artificial meat flavor; 
 iii) a binder which is polyethylene glycol; 
 iv) a solvent which is triglyceride; 
 v) a surfactant which is sodium lauryl sulfate; 
 vi) a humectant which is glycerol; 
 vii) optionally an antioxidant; and 
 viii) optionally a preservative.