Tdf-related compounds and analogs thereof

Abstract

The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.

1 . A compound comprising an amino acid sequence selected from the group consisting of SEQ TD NOs: 1-314 and variants, analogs, homologs, or fragments thereof. 
     
     
         2 .- 6 . (canceled) 
     
     
         7 . A pharmaceutical composition comprising a compound of  claim 1 , and a pharmaceutically acceptable carrier. 
     
     
         8 .- 23 . (canceled) 
     
     
         24 . A kit comprising in one or more containers, the pharmaceutical composition of  claim 7  and instructions for using the contents therein. 
     
     
         25 .- 31 . (canceled) 
     
     
         32 . A compound for use in treating a tissue differentiation factor-associated disorder or disease, wherein the compound is selected from the group consisting of SEQ ID NOs: 1-314. 
     
     
         33 .- 47 . (canceled) 
     
     
         48 . A device comprising an implantable medical device having a coating wherein the coating is comprised of an amino acid sequence selected from the group consisting of, SEQ ID NOs:1-314 and variants, analogs, homologs, or fragments thereof, and wherein the device, when implanted into a mammal, treats or prevents a disorder in the mammal. 
     
     
         49 .- 69 . (canceled)