Polymer Scaffold Degradation Control Via Chemical Control

Abstract

A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.

1 . A copolymer comprising maleate and fumarate monomers, wherein the copolymer has a rate of degradation that is faster than poly(propylene fumarate) (PPF). 
     
     
         2 . The copolymer of  claim 1  wherein the maleate and fumarate monomers are present in a known stoichiometric ratio. 
     
     
         3 . The copolymer of  claim 1  wherein the monomers have a molecular weight of less than 10,000. 
     
     
         4 . The copolymer of  claim 1  wherein the monomers have a molecular weight of less than 5,000. 
     
     
         5 . The copolymer of  claim 1  wherein the monomers have a molecular weight of less than 1,000. 
     
     
         6 . The copolymer of  claim 1  having a glass transition temperature less than 0° C. 
     
     
         7 . The copolymer of  claim 1  wherein the copolymer is an unsaturated polyester. 
     
     
         8 . A copolymer consisting comprising of maleate and fumarate monomers in a known stoichiometric ratio and a cross-linking agent. 
     
     
         9 . (canceled) 
     
     
         10 . The copolymer of  claim 8  wherein the monomers have a molecular weight of less than 1,000. 
     
     
         11 . The copolymer of  claim 8  wherein the copolymer consists of maleate and fumerate monomers. 
     
     
         12 . The copolymer of  claim 11  wherein the maleate and fumarate monomers are present in a known stoichiometric ratio. 
     
     
         13 . The copolymer of  claim 11  wherein the monomers have a molecular weight of less than 1,000. 
     
     
         14 . The copolymer of  claim 1  further comprising glycol. 
     
     
         15 . The copolymer of  claim 8  further comprising glycol.