Bioabsorbable medical device with coating

Abstract

A biodegradable, bioabsorbable medical device with a coating for capturing progenitor endothelial cells in vivo and delivering a therapeutic agent at the site of implantation. The coating on the medical device is provided with a biabsorbable polymer composition such as a bioabsorbable polymer, copolymer, or terpolymer, and a copolymer or terpolymer additive for controlling the rate of delivery of the therapeutic agent.

What is claimed is: 
     
         1 . An expandable stent, comprising bioabsorbable material and a coating, wherein the expandable stent comprises a plurality of first meandering strut patterns forming an interconnected mesh, and at least one second strut pattern comprising a hoop circumferential about the longitudinal axis of the expandable stent, wherein the second strut pattern crystallizes when the stent is expanded, and wherein the coating comprises a bioabsorbable matrix 
     
     
         2 . An expandable stent of  claim 1  comprising a main body, wherein the main body has a generally cylindrical shape and a cylindrical axis and, when the stent is unexpanded, the main body comprises a plurality of expandable helical segments, characterized in that the main body further comprises:
 a plurality of main body cylindrical elements having collinear cylindrical axes; 
 wherein the main body cylindrical elements are adjacent one another and attached to one another by the helical segments, each main body cylindrical element ( 100 ) having a circumference that is substantially identical to that of an adjacent cylindrical element, and comprising a plurality of expandable circumferential segments, wherein the circumferential segments are joined together by portions of the helical segments to form the cylindrical elements, and the plurality of circumferential segments comprise a majority of the circumference of each cylindrical element. 
 
     
     
         3 . The expandable stent of  claim 1 , wherein the bioabsorbable material comprises at least poly-L-lactide (PLLA). 
     
     
         4 . The expandable stent of  claim 1 , wherein the bioabsorbable matrix comprises a natural or synthetic biodegradable polymer. 
     
     
         5 . The expandable stent of  claim 1 , wherein the bioabsorbable matrix comprises at least one of the group consisting of:
 absorbable polymer, dextran, tropoelastin, elastin, laminin, fibronectin, fibrin, collagen, basement membrane proteins, and cross-linked tropoelastin.   
     
     
         6 . The expandable stent coating of  claim 1 , comprising a pharmacological substance. 
     
     
         7 . The expandable stent of  claim 6 , wherein the pharmacological substance is at least one of the group consisting of: cyclosporin A, mycophenolic acid, mycophenolate mofetil acid, rapamycin, rapamycin derivatives, biolimus A9, CCI779, RAD 001, AP23573, azathioprene, pimecrolimus, tacrolimus (FK506), tranilast, dexamethasone, corticosteroid, everolimus, retinoic acid, vitamin E, rosglitazone, simvastatins, fluvastatin, estrogen, 17-estradiol, hydrocortisone, acetaminophen, ibuprofen, naproxen, fluticasone, clobetasol, adalimumab, sulindac, dihydroepiandrosterone, testosterone, puerarin, platelet factor 4, basic fibroblast growth factor, fibronectin, butyric acid, butyric acid derivatives, paclitaxel, paclitaxel derivatives, LBM-642, deforolimus, and probucol.