US2016207927A1PendingUtilityA1
Pyrimidine substituted purine compounds as kinase (s) inhibitors
Est. expiryApr 3, 2029(~2.7 yrs left)· nominal 20-yr term from priority
A61P 3/10A61P 35/04A61P 9/00A61P 37/08A61P 5/14A61P 37/06A61P 43/00A61P 37/02A61P 7/04A61P 35/00A61P 9/10A61P 7/06A61P 37/00A61P 7/00A61P 35/02A61P 27/02A61P 25/00A61P 29/00C12N 9/1205C07D 487/04A61P 11/06C12Y 207/01137A61P 11/00A61P 21/04A61P 1/16A61P 15/00C07D 473/32A61P 11/02A61P 17/14C12Y 207/11001A61P 17/04C12N 9/12A61P 1/00A61P 19/02A61P 13/08A61P 17/00A61K 31/5377A61P 1/04A61P 13/12A61P 17/06Y02A50/30
50
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Claims
Abstract
The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure: or a pharmaceutically acceptable salt thereof
Claims
exact text as granted — not AI-modified1 - 46 . (canceled)
47 . A method of making a compound of Formula (I), the method comprising
reacting a compound of Formula (II)
with dimethyl zinc,
thereby providing the compound of Formula (I).
48 . The method of claim 47 , wherein the reaction is performed in the presence of a palladium complex.
49 . The method of claim 48 , wherein the palladium complex is Pd(dppf)Cl 2 .
50 . The method of claim 47 , wherein the reaction is performed in the presence of a solvent.
51 . The method of claim 50 , wherein the solvent is dioxane.
52 . The method of claim 47 , wherein the temperature is about 65° C.
53 . A method of making a compound of the Formula (II), the method comprising
reacting a compound of the Formula (III) with N-Bromosuccinimide,
thereby providing the compound of Formula (II).
54 . The method of claim 53 , wherein the reaction is performed in the presence of a solvent.
55 . The method of claim 54 , wherein the solvent is chloroform.
56 . The method of claim 53 , wherein the temperature is about 5° C.
57 . A method of making a compound of the Formula (III), the method comprising
reacting a compound of the Formula (IV) with morpholine,
thereby providing the compound of Formula (III).
58 . The method of claim 57 , wherein the reaction is performed in the presence of a solvent.
59 . The method of claim 58 , wherein the solvent is dimethyl acetamide.
60 . The method of claim 57 , wherein the temperature is around 94° C.
61 . A method of making a compound of the Formula (IV), the method comprising
reacting a compound of the Formula (V) with a compound of the Formula (VI),
thereby providing the compound of Formula (IV).
62 . The method of claim 61 , wherein the reaction is performed in the presence of a solvent.
63 . The method of claim 62 , wherein the solvent is dichloromethane.
64 . The method of claim 61 , wherein the reaction is performed in the presence of a palladium complex.
65 . The method of claim 64 , wherein the palladium complex is 1,1′-bis(diphenylphosphino) ferrocene palladium (II) chloride.
66 . The method of claim 61 , wherein the reaction is performed in the presence of a base.
67 . The method of claim 61 , wherein the temperature is about 80° C.Cited by (0)
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