Biodegradable polymer and tissue combinations

Abstract

A biodegradable bioprosthesis can include a biodegradable tissue and a biodegradable polymer combined with the biodegradable tissue. The biodegradable tissue can be non-crosslinked tissue, EDC crosslinked tissue or tissue crosslinked using biodegradable crosslinker. The biodegradable polymer can be a crosslinked polymer and/or synthetic polymer. The bioprosthesis can include a bioactive agent (rifampin). The biodegradable tissue and biodegradable polymer can form a drug delivery patch having the bioactive agent. The bioactive agent can be an antimicrobial. The biodegradable tissue can be decellularized. A method of making the biodegradable bioprosthesis can include treating the biodegradable tissue with a fluid having the biodegradable polymer. A method of implanting a biodegradable bioprosthesis can include implanting the bioprosthesis in a subject, where the bioprosthesis is implanted for repairing a hernia and/or the bioprosthesis inhibits post-operative adhesions.

1 . A biodegradable bioprosthesis comprising:
 a biodegradable tissue; and   a biodegradable polymer combined with the biodegradable tissue.   
     
     
         2 . The bioprosthesis of  claim 1 , wherein the biodegradable tissue is non-crosslinked tissue, EDC crosslinked tissue or tissue crosslinked using biodegradable crosslinker. 
     
     
         3 . The bioprosthesis of  claim 1 , wherein the biodegradable polymer is selected from polylactones, polyhydroxy acids, polylactide poly-L-lactides (PLLA), poly-D-lactides (PDLA), poly-DL-Lactides (PLA), polyglycolides (PGA), polylactide-polyglycolide copolymers; polydioxanones, polycaprolactones (PCL), polyhydroxyalkanoates, poly(3-hydroxybutyrate), 3-hydroxyvalerate, 4-hydroxybutarate, 3-hydroxyhexanoate, 3-hydroxyoctanoate, polycaprolactone-polyglycolide copolymers, polyethylene oxides, polylactone-polyethylene oxide copolymers, modified cellulose, collagen, poly(hydroxybutyrate), polyanhydride, polyphosphoester, poly(amino acids), poly(alpha-hydroxy acid) or copolymers thereof. 
     
     
         4 . The bioprosthesis of  claim 1 , wherein the biodegradable polymer is a crosslinked polymer. 
     
     
         5 . The bioprosthesis of  claim 1 , wherein the biodegradable polymer is a synthetic polymer. 
     
     
         6 . The bioprosthesis of  claim 1 , further comprising at least one bioactive agent. 
     
     
         7 . The bioprosthesis of  claim 6 , wherein the biodegradable tissue and biodegradable polymer form a drug delivery patch having the at least one bioactive agent. 
     
     
         8 . The bioprosthesis of  claim 6 , wherein the bioactive agent is an antimicrobial. 
     
     
         9 . The bioprosthesis of  claim 1 , wherein the biodegradable tissue and biodegradable polymer form a composite. 
     
     
         10 . The bioprosthesis of  claim 1 , wherein the biodegradable polymer is coated on the biodegradable tissue. 
     
     
         11 . The bioprosthesis of  claim 1 , wherein the biodegradable polymer is at about 1% to 70%. 
     
     
         12 . The bioprosthesis of  claim 6 , wherein the at least one bioactive agent includes rifampin. 
     
     
         13 . The bioprosthesis of  claim 10 , wherein the biodegradable polymer coating is about 0.1 microns to about 5 mm thick. 
     
     
         14 . The bioprosthesis of  claim 1 , wherein the biodegradable tissue is decellularized. 
     
     
         15 . The bioprosthesis of  claim 6 , wherein the bioactive agent is included at about 0.1% to about 90%. 
     
     
         16 . The bioprosthesis of  claim 1 , further comprising a plurality of biodegradable polymer coatings on the biodegradable tissue. 
     
     
         17 . The bioprosthesis of  claim 16 , wherein at least one of the coatings includes a bioactive agent, and at least one coating is a diffusion barrier coating over the coating having the bioactive agent. 
     
     
         18 . The bioprosthesis of  claim 1 , wherein the biodegradable tissue is a membrane or sheet. 
     
     
         19 . The bioprosthesis of  claim 1 , wherein the biodegradable tissue is pericardial tissue, bladder tissue, submucosa tissue, skin tissue, placenta tissue, umbilical cord tissue, amniotic membrane tissue, or cultured tissue. 
     
     
         20 . A method of making the biodegradable bioprosthesis of  claim 1 , comprising:
 treating the biodegradable tissue with a fluid having the biodegradable polymer.   
     
     
         21 . The method of  claim 20 , wherein the fluid is a solvent for the biodegradable polymer. 
     
     
         22 . The method of  claim 20 , further comprising introducing a bioactive agent into the biodegradable tissue with the fluid having the biodegradable polymer. 
     
     
         23 . The method of  claim 20 , further comprising: dehydrating the biodegradable tissue before the treating. 
     
     
         24 . The method of  claim 20 , further comprising removing the fluid from the biodegradable tissue so as to leave the biodegradable polymer with the biodegradable tissue. 
     
     
         25 . The method of  claim 20 , further comprising coating the biodegradable polymer onto the biodegradable tissue. 
     
     
         26 . The method of  claim 25 , wherein the coating is via dip coating or spray coating. 
     
     
         27 . The method of  claim 20 , wherein the biodegradable tissue as decellularized tissue. 
     
     
         28 . A method of implanting a biodegradable implant, the method comprising:
 providing the bioprosthesis of  claim 1 ;   implanting the bioprosthesis in a subject.   
     
     
         29 . The method of  claim 28 , wherein the bioprosthesis is implanted for repairing a hernia. 
     
     
         30 . The method of  claim 28 , wherein the bioprosthesis inhibits post-operative adhesions.