Refractive-diffractive ophthalmic device and compositions useful for producing same

Abstract

Provided herein is a multifocal ophthalmic device comprising a lens body being formed with a plurality of concentric annular zones separated by slanted steps which effect both diffraction and refraction of incident light, while being devoid of any diffractive or refractive power, whereas the lens body is made from a co-polymeric composition based on less than 75% aromatic acrylate monomers, and includes a curcuminoid compound as a UV-light stabilizer; as well as use of the device for treating ophthalmologic and/or esthetic condition associated with an eye.

What is claimed is: 
     
         1 . A multifocal ophthalmic device comprising a lens body being formed with a plurality of concentric annular zones separated by slanted steps, wherein said concentric zones effect both diffraction and refraction of incident light, while said steps are substantially devoid of any diffractive or refractive power, said lens body comprises a polymeric or co-polymeric composition derived from a pre-polymerization mixture of monomers which comprises less than 75% of aromatic acrylate monomers. 
     
     
         2 . The device of  claim 1 , wherein at least one curcuminoid compound is incorporated in or on said polymeric or co-polymeric composition and/or said lens body. 
     
     
         3 . The device of  claim 2 , wherein a concentration of said curcuminoid compound ranges from 0.0002 weight percentage to 1 weight percentage of the total weight of the composition. 
     
     
         4 . The device of  claim 1 , wherein said polymeric or co-polymeric composition is derived from a pre-polymerization mixture of monomers which comprises at least 50 weight percent acrylate monomers. 
     
     
         5 . The device of  claim 1 , wherein said co-polymeric composition comprises a polymeric backbone composed of a plurality of backbone units covalently linked to one another, said backbone units being derived from a pre-polymerization mixture of monomers which comprises:
 a first aromatic acrylate monomer, characterized as forming a first homopolymer having a refractive index that ranges from 1.50 to 1.53; and   a second aromatic acrylate monomer, characterized as forming a second homopolymer having a Tg lower by a range of 2° C. to 30° C. than a Tg of said first homopolymer;   wherein:   a concentration of said first aromatic acrylate monomer ranges from 50% to 60% of the total weight of the composition; and   a concentration of said second aromatic acrylate monomer ranges from 15% to 20% of the total weight of the composition.   
     
     
         6 . The device of  claim 5 , wherein said pre-polymerization mixture further comprises:
 a third monomer, characterized as forming a third homopolymer having a Tg lower than 35° C.;   a fourth monomer, characterized as forming a fourth homopolymer which is capable of absorbing water to at least 20% of the total weight of said fourth homopolymer; and   a fifth monomer, being a crosslinking monomer,   wherein:   a concentration of said third monomer ranges from 10% to 15% of the total weight of the composition;   a concentration of said fourth monomer ranges from 5% to 10% of the total weight of the composition; and   a concentration of said fifth monomer ranges from 2% to 5% of the total weight of the composition.   
     
     
         7 . The device of  claim 1 , wherein said lens body has an aspheric profile. 
     
     
         8 . The device of  claim 7 , wherein said aspheric profile is characterized by a conic constant in a range of from about −1.0 to about −3.0, inclusive. 
     
     
         9 . The device of  claim 1 , wherein each step of said steps has a width which is from about 0.17 microns to about 0.2 microns. 
     
     
         10 . The device of  claim 1 , wherein said heights vary from about 1.83 micron at said center to about 0.09 micron at said edge. 
     
     
         11 . The device of  claim 1 , wherein said slopes vary from about 84° at said center to about 25° at said edge. 
     
     
         12 . The device of  claim 5 , having a refractive index of at least 1.53. 
     
     
         13 . The device of  claim 5 , characterized by a glass transition temperature not higher than 5° C. 
     
     
         14 . The device of  claim 1 , being substantially transparent to light at a wavelength ranging from about 400 to about 800 nm. 
     
     
         15 . The device of  claim 1 , being substantially opaque to light at a wavelength ranging from about 190 to about 440. 
     
     
         16 . The device of  claim 1 , being selected from the group consisting of a contact lens and an implantable ocular device. 
     
     
         17 . The device of  claim 1 , suitable for use as an optical distortion corrective device, a retinopathy corrective device, a retinal detachment corrective device, an occlusion corrective device, a proliferative retinopathy corrective device, a proliferative vitreoretinopathy corrective device, a diabetic retinopathy corrective device, a degenerative disease corrective device and an age-related macular degeneration corrective device. 
     
     
         18 . A method of treating a medical, ophthalmologic and/or esthetic condition associated with an eye of a subject in need thereof, comprising implanting the multifocal ophthalmic device of  claim 1  in an eye of the subject, thereby treating the condition. 
     
     
         19 . The method of  claim 18 , wherein said condition is selected from the group consisting of an optical distortion, optical corrective treatment, retinopathy, retinal detachment, occlusion, proliferative retinopathy, proliferative vitreoretinopathy, diabetic retinopathy, degenerative disease and an age-related macular degeneration.