Fc receptor binding proteins

Abstract

This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

1 - 59 . (canceled) 
     
     
         60 . An isolated nucleic acid comprising a sequence that encodes a polypeptide that includes a sequence at least 80% identical to the sequence of a variable domain of M0171-A03, M0171-A01, M0159-A07 or M0161-B04. 
     
     
         61 . The isolated nucleotide sequence of claim  1 , wherein the sequence encodes a polypeptide comprising the first and/or second immunoglobulin variable domain of an antibody, wherein the antibody comprises a heavy chain (HC) immunoglobulin variable domain sequence and a light chain (LC) immunoglobulin variable domain sequence; and wherein
 the HC comprises:
 a HC CDR1 comprising the amino acid sequence EYAMG (SEQ ID NO:144) or VYAMG (SEQ ID NO:156), 
 a HC CDR2 comprising the amino acid sequence SIGSSGGQTKYADSVKG (SEQ ID NO:145) or SIGSSGGPTKYADSVKG (SEQ ID NO:157), and 
 a HC CDR3 comprising the amino acid sequence LSTGELY (SEQ ID NO:146), LSIRELV (SEQ ID NO:158), LSIVDSY (SEQ ID NO:164), LSLGDSY (SEQ ID NO:170), or, LAIGDSY (SEQ ID NO:176); and 
   the LC comprises:
 a LC CDR1 comprising the amino acid sequence TGTGSDVGSYNLVS (SEQ ID NO:141), 
 a LC CDR2 comprising the amino acid sequence GDSQRPS (SEQ ID NO:142), and 
 a LC CDR3 comprising the amino acid sequence CSYAGSGIYV (SEQ ID NO:143). 
   
     
     
         62 - 110 . (canceled) 
     
     
         111 . A vector comprising the nucleic acid sequence of  claim 60 . 
     
     
         112 . A host cell comprising the nucleic acid of  claim 60 . 
     
     
         113 . The isolated nucleotide sequence of  claim 60 , wherein the sequence encodes a polypeptide comprising the first and/or second immunoglobulin variable domain of M0171-A03, M0171-A01, M0159-A07 or M0161-B04.